PDF(Pubmed)
Abstract：
UNASSIGNED: Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disorder of the central nervous system, which is associated with brain atrophy and volume changes in some brain structures. This study aimed to compare the volume of the basal ganglia, thalamus, cerebellum, and brainstem in patients with relapsing-remitting MS with that of the control group using magnetic resonance imaging (MRI).
UNASSIGNED: In this cross-sectional study, MRI brain scans were obtained from 25 patients with relapsing-remitting MS and 25 healthy control subjects. Volumetric analyses were performed using Brain Suite software.
UNASSIGNED: The mean age of the MS and the control groups was 33.96±8.75 and 40.40±8.72, respectively. No statistically significant difference was found in gender (P=0.747). The bilateral putamen and caudate nuclei volumes were significantly higher in the case group than in the control group (P<0.001). Moreover, lower the volume of the brainstem, cerebellum, bilateral thalamus, and globus pallidus were identified in the MS patients compared to the control group (P<0.001). There was an inverse correlation between the disease and treatment duration with the thalamus and cerebellum volume in MS patients (P=0.001). Treatment duration also had an inverse correlation with brainstem volume (P=0.047).
UNASSIGNED: The volume of some structures of the brain, including globus pallidus, thalamus, cerebellum, and brainstem is lower in MS and can be one of the markers of disease progression and disability among MS patients.
UNASSIGNED: Due to the degenerative process in multiple sclerosis, some cerebral structures may face volume change.The present study demonstrated that the volume of globus pallidus, thalamus, cerebellum, and brainstem is lower in MS patients compared to the controls.
UNASSIGNED: Multiple sclerosis (MS) is defined as an inflammatory disease involving the white matter of the brain, but experience has shown that many non-white matter structures also change in MS. In this study, we aimed to examine some parts of the brain, such as the thalamus, basal ganglia, brainstem, and cerebellum, for volume changes. The results showed that all these structures can have a smaller volume in MS patients than in healthy people. Especially in the case of the thalamus and cerebellum, this difference increases with increasing the disease duration. Changes in the size of these structures can be the result of degeneration of the neurons in these areas. These changes can cause significant disability in patients; however, there may not be significant changes in the number of plaques in patients. Attention to these changes can be essential in interpreting patients\' clinical changes, including motor and cognitive disabilities.
UNASSIGNED: In this cross-sectional study, MRI brain scans were obtained from 25 patients with relapsing-remitting MS and 25 healthy control subjects. Volumetric analyses were performed using Brain Suite software.
UNASSIGNED: The mean age of the MS and the control groups was 33.96±8.75 and 40.40±8.72, respectively. No statistically significant difference was found in gender (P=0.747). The bilateral putamen and caudate nuclei volumes were significantly higher in the case group than in the control group (P<0.001). Moreover, lower the volume of the brainstem, cerebellum, bilateral thalamus, and globus pallidus were identified in the MS patients compared to the control group (P<0.001). There was an inverse correlation between the disease and treatment duration with the thalamus and cerebellum volume in MS patients (P=0.001). Treatment duration also had an inverse correlation with brainstem volume (P=0.047).
UNASSIGNED: The volume of some structures of the brain, including globus pallidus, thalamus, cerebellum, and brainstem is lower in MS and can be one of the markers of disease progression and disability among MS patients.
UNASSIGNED: Due to the degenerative process in multiple sclerosis, some cerebral structures may face volume change.The present study demonstrated that the volume of globus pallidus, thalamus, cerebellum, and brainstem is lower in MS patients compared to the controls.
UNASSIGNED: Multiple sclerosis (MS) is defined as an inflammatory disease involving the white matter of the brain, but experience has shown that many non-white matter structures also change in MS. In this study, we aimed to examine some parts of the brain, such as the thalamus, basal ganglia, brainstem, and cerebellum, for volume changes. The results showed that all these structures can have a smaller volume in MS patients than in healthy people. Especially in the case of the thalamus and cerebellum, this difference increases with increasing the disease duration. Changes in the size of these structures can be the result of degeneration of the neurons in these areas. These changes can cause significant disability in patients; however, there may not be significant changes in the number of plaques in patients. Attention to these changes can be essential in interpreting patients\' clinical changes, including motor and cognitive disabilities.
摘要：
■多发性硬化症（MS）是中枢神经系统的炎性脱髓鞘和神经退行性疾病，这与脑萎缩和一些大脑结构的体积变化有关。本研究旨在比较基底神经节的体积，丘脑,小脑,复发缓解型MS患者的脑干与对照组使用磁共振成像（MRI）。
■在这项横断面研究中，从25名复发缓解型MS患者和25名健康对照受试者获得MRI脑部扫描。使用BrainSuite软件进行体积分析。
■MS组和对照组的平均年龄分别为33.96±8.75和40.40±8.72。性别差异无统计学意义(P=0.747)。病例组双侧壳核和尾状核体积明显高于对照组(P<0.001)。此外，降低脑干的体积，小脑,双侧丘脑,与对照组相比，MS患者中发现了苍白球（P<0.001）。MS患者的病情和治疗时间与丘脑和小脑体积呈负相关（P=0.001）。治疗持续时间与脑干体积呈负相关(P=0.047)。
■大脑某些结构的体积，包括苍白球,丘脑,小脑,MS患者脑干较低，可能是MS患者疾病进展和残疾的标志物之一。
■由于多发性硬化症的退行性过程，一些大脑结构可能面临体积变化。本研究表明苍白球的体积，丘脑,小脑,与对照组相比，MS患者的脑干较低。
■多发性硬化症（MS）被定义为涉及大脑白质的炎症性疾病，但是经验表明，MS中许多非白质结构也会发生变化。在这项研究中,我们的目的是检查大脑的某些部分，比如丘脑，基底神经节,脑干,还有小脑,量的变化。结果表明，所有这些结构在MS患者中的体积都比健康人小。特别是在丘脑和小脑的情况下，这种差异随着疾病持续时间的增加而增加。这些结构的大小变化可能是这些区域中神经元退化的结果。这些变化可能会导致患者严重残疾;然而，患者的斑块数量可能没有显著变化.注意这些变化对于解释患者的临床变化至关重要，包括运动障碍和认知障碍。
■在这项横断面研究中，从25名复发缓解型MS患者和25名健康对照受试者获得MRI脑部扫描。使用BrainSuite软件进行体积分析。
■MS组和对照组的平均年龄分别为33.96±8.75和40.40±8.72。性别差异无统计学意义(P=0.747)。病例组双侧壳核和尾状核体积明显高于对照组(P<0.001)。此外，降低脑干的体积，小脑,双侧丘脑,与对照组相比，MS患者中发现了苍白球（P<0.001）。MS患者的病情和治疗时间与丘脑和小脑体积呈负相关（P=0.001）。治疗持续时间与脑干体积呈负相关(P=0.047)。
■大脑某些结构的体积，包括苍白球,丘脑,小脑,MS患者脑干较低，可能是MS患者疾病进展和残疾的标志物之一。
■由于多发性硬化症的退行性过程，一些大脑结构可能面临体积变化。本研究表明苍白球的体积，丘脑,小脑,与对照组相比，MS患者的脑干较低。
■多发性硬化症（MS）被定义为涉及大脑白质的炎症性疾病，但是经验表明，MS中许多非白质结构也会发生变化。在这项研究中,我们的目的是检查大脑的某些部分，比如丘脑，基底神经节,脑干,还有小脑,量的变化。结果表明，所有这些结构在MS患者中的体积都比健康人小。特别是在丘脑和小脑的情况下，这种差异随着疾病持续时间的增加而增加。这些结构的大小变化可能是这些区域中神经元退化的结果。这些变化可能会导致患者严重残疾;然而，患者的斑块数量可能没有显著变化.注意这些变化对于解释患者的临床变化至关重要，包括运动障碍和认知障碍。
