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Abstract：
Objectives. This study aimed to find the association between clinical characteristics, cytogenetics, and post-induction outcomes of childhood acute lymphoblastic leukemia. Methods. The study was conducted at the Indus Hospital in Karachi. Initial total leukocyte count (TLC), cytogenetics, CNS status, and post-induction remission status were recorded. Results. Out of 108 children diagnosed with ALL, 66 (61.1%) were male and 42 (38.9%) were female. The majority 90 (83.3%) had B-ALL. CNS1 status was observed in 76 (84.4%) B-ALL and 18 (88.9%) T-ALL. All T-ALL and 89 (98.8%) B-ALL achieved remission post-induction. In B-ALL, 50 (55.5%) had a normal diploid karyotype, and 22 (24.4%) had numerical abnormalities. No typical gene rearrangement was observed in 66 (73.3%), 11 (12.2%) had BCR::ABL1, 10 (11.1%) had ETV6::RUNX1 and 3 (3.3%) KMT2A on FISH. No significant difference was observed between cytogenetics and clinical characteristics (P > .05). Conclusion. The study provides valuable data on childhood acute lymphoblastic leukemia in the Pakistani population.
摘要：
Objectives.本研究旨在发现临床特征之间的关联，细胞遗传学,和儿童急性淋巴细胞白血病的诱导后结局。方法。这项研究是在卡拉奇的印度河医院进行的。初始总白细胞计数（TLC），细胞遗传学,CNS状态，并记录诱导后缓解状态。结果。在被诊断为ALL的108名儿童中，男性66人（61.1%），女性42人（38.9%）。大多数90（83.3％）患有B-ALL。在76(84.4%)B-ALL和18(88.9%)T-ALL中观察到CNS1状态。所有T-ALL和89(98.8%)B-ALL在诱导后达到缓解。在B-ALL中,50（55.5％）具有正常的二倍体核型，22例(24.4%)有数值异常。66例（73.3%）未观察到典型的基因重排，11（12.2%）有BCR::ABL1，10（11.1%）有ETV6::RUNX1和3（3.3%）KMT2A在FISH上。在细胞遗传学和临床特征之间没有观察到显着差异（P>0.05）。结论。该研究提供了有关巴基斯坦儿童急性淋巴细胞白血病的宝贵数据。
