PDF(Pubmed)
Abstract：
UNASSIGNED: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging epidemic infectious disease with high mortality rate. This study aimed to investigate the association of red blood cell distribution width (RDW) and mortality risk in hospitalized SFTS patients.
UNASSIGNED: Clinical data of SFTS patients was retrospectively collected from three hospitals between October 2010 and August 2022. Cox proportional hazards model was used to identity the risk factors for fatal outcome. The predictive value of RDW for fatal outcome was evaluated by the receiver operating characteristic (ROC) analysis and Kaplan-Meier methods.
UNASSIGNED: Of 292 patients, the median age was 61.5 years. Non-survivors showed higher RDW value than survivors (13.6% vs.13.0%, P < 0.001). The mortality rate was 44.8% in patients with elevated RDW compared to 18.4% of patients with normal RDW, with a relative risk (RR) of 2.439. Elevated RDW was an independent risk factor of mortality (hazards ratio: 1.167, P = 0.019). Patients with elevated RDW had a higher cumulative mortality than patients with normal RDW. The area under the ROC curve (AUC) of RDW for the prediction of mortality was 0.690 (P < 0.001).
UNASSIGNED: Elevated RDW was associated with higher mortality risk for patients hospitalized for SFTS. RDW may be helpful for risk stratification in SFTS patients.
UNASSIGNED: Clinical data of SFTS patients was retrospectively collected from three hospitals between October 2010 and August 2022. Cox proportional hazards model was used to identity the risk factors for fatal outcome. The predictive value of RDW for fatal outcome was evaluated by the receiver operating characteristic (ROC) analysis and Kaplan-Meier methods.
UNASSIGNED: Of 292 patients, the median age was 61.5 years. Non-survivors showed higher RDW value than survivors (13.6% vs.13.0%, P < 0.001). The mortality rate was 44.8% in patients with elevated RDW compared to 18.4% of patients with normal RDW, with a relative risk (RR) of 2.439. Elevated RDW was an independent risk factor of mortality (hazards ratio: 1.167, P = 0.019). Patients with elevated RDW had a higher cumulative mortality than patients with normal RDW. The area under the ROC curve (AUC) of RDW for the prediction of mortality was 0.690 (P < 0.001).
UNASSIGNED: Elevated RDW was associated with higher mortality risk for patients hospitalized for SFTS. RDW may be helpful for risk stratification in SFTS patients.
摘要：
■严重发热伴血小板减少综合征（SFTS）是一种新兴的流行性传染病，死亡率高。本研究旨在探讨红细胞分布宽度(RDW)与住院SFTS患者死亡风险的关系。
■在2010年10月至2022年8月期间，从三家医院回顾性收集了SFTS患者的临床数据。Cox比例风险模型用于确定致命结局的危险因素。通过受试者工作特征（ROC）分析和Kaplan-Meier方法评估RDW对致命结局的预测价值。
■在292名患者中，中位年龄为61.5岁.非幸存者的RDW值高于幸存者（13.6%vs.13.0%，P<0.001)。RDW升高患者的死亡率为44.8%，而RDW正常患者的死亡率为18.4%，相对风险(RR)为2.439。RDW升高是死亡的独立危险因素(危险比:1.167,P=0.019)。RDW升高患者的累积死亡率高于RDW正常患者。RDW预测死亡率的ROC曲线下面积(AUC)为0.690(P<0.001)。
■对于因SFTS住院的患者，RDW升高与较高的死亡风险相关。RDW可能有助于SFTS患者的风险分层。
■在2010年10月至2022年8月期间，从三家医院回顾性收集了SFTS患者的临床数据。Cox比例风险模型用于确定致命结局的危险因素。通过受试者工作特征（ROC）分析和Kaplan-Meier方法评估RDW对致命结局的预测价值。
■在292名患者中，中位年龄为61.5岁.非幸存者的RDW值高于幸存者（13.6%vs.13.0%，P<0.001)。RDW升高患者的死亡率为44.8%，而RDW正常患者的死亡率为18.4%，相对风险(RR)为2.439。RDW升高是死亡的独立危险因素(危险比:1.167,P=0.019)。RDW升高患者的累积死亡率高于RDW正常患者。RDW预测死亡率的ROC曲线下面积(AUC)为0.690(P<0.001)。
■对于因SFTS住院的患者，RDW升高与较高的死亡风险相关。RDW可能有助于SFTS患者的风险分层。
