PDF(Pubmed)
Abstract：
UNASSIGNED: This present study evaluated the effect of combination therapy with stromal cell-derived factor 1α (SDF-1α) and high-mobility group box 1 (HMGB1) peptide on the regeneration of tracheal injury in a rat model.
UNASSIGNED: To improve this effect, SDF-1α was incorporated into a gelatin hydrogel, which was then applied to the damaged tracheal cartilage of rats for local release. Furthermore, HMGB1 peptide was repeatedly administered intravenously. Regeneration of damaged tracheal cartilage was evaluated in terms of cell recruitment.
UNASSIGNED: Mesenchymal stem cells (MSC) with C-X-C motif chemokine receptor 4 (CXCR4) were mobilized more into the injured area, and consequently the fastest tracheal cartilage regeneration was observed in the combination therapy group eight weeks after injury.
UNASSIGNED: The present study demonstrated that combination therapy with gelatin hydrogel incorporating SDF-1α and HMGB1 peptide injected intravenously can enhance the recruitment of CXCR4-positive MSC, promoting the regeneration of damaged tracheal cartilage.
UNASSIGNED: To improve this effect, SDF-1α was incorporated into a gelatin hydrogel, which was then applied to the damaged tracheal cartilage of rats for local release. Furthermore, HMGB1 peptide was repeatedly administered intravenously. Regeneration of damaged tracheal cartilage was evaluated in terms of cell recruitment.
UNASSIGNED: Mesenchymal stem cells (MSC) with C-X-C motif chemokine receptor 4 (CXCR4) were mobilized more into the injured area, and consequently the fastest tracheal cartilage regeneration was observed in the combination therapy group eight weeks after injury.
UNASSIGNED: The present study demonstrated that combination therapy with gelatin hydrogel incorporating SDF-1α and HMGB1 peptide injected intravenously can enhance the recruitment of CXCR4-positive MSC, promoting the regeneration of damaged tracheal cartilage.
摘要：
■本研究评估了基质细胞衍生因子1α（SDF-1α）和高迁移率族蛋白1（HMGB1）肽联合治疗对大鼠气管损伤再生的影响。
■为了改善这种效果，将SDF-1α掺入明胶水凝胶中，然后将其应用于大鼠受损的气管软骨进行局部释放。此外，静脉内重复施用HMGB1肽。根据细胞募集评估受损的气管软骨的再生。
■具有C-X-C基序趋化因子受体4（CXCR4）的间充质干细胞（MSC）被更多地动员到受伤区域，因此，在受伤后八周的联合治疗组中观察到最快的气管软骨再生。
■本研究表明，静脉注射含有SDF-1α和HMGB1肽的明胶水凝胶的联合治疗可以增强CXCR4阳性MSC的募集，促进受损气管软骨的再生。
■为了改善这种效果，将SDF-1α掺入明胶水凝胶中，然后将其应用于大鼠受损的气管软骨进行局部释放。此外，静脉内重复施用HMGB1肽。根据细胞募集评估受损的气管软骨的再生。
■具有C-X-C基序趋化因子受体4（CXCR4）的间充质干细胞（MSC）被更多地动员到受伤区域，因此，在受伤后八周的联合治疗组中观察到最快的气管软骨再生。
■本研究表明，静脉注射含有SDF-1α和HMGB1肽的明胶水凝胶的联合治疗可以增强CXCR4阳性MSC的募集，促进受损气管软骨的再生。
