PDF(Pubmed)
Abstract：
Cerebral small vessel disease (CSVD) is a prevalent vascular disorder that has been consistently associated with vascular cognitive impairment (VCI). The diagnosis of CSVD continues to rely on magnetic resonance imaging (MRI). Epidemiological data indicate that the characteristic MRI features of CSVD, including white matter hyperintensity (WMH) and lacunar infarction, are very common among individuals over 40 years of age in community studies. This prevalence poses a significant burden on many low- and middle-income families. The amygdala plays a crucial role in integrating sensory and associative information to regulate emotional cognition. Although many previous studies have linked alterations in the amygdala to various diseases, such as depression, there has been little research on CSVD-associated alterations in the amygdala due to the complexity of CSVD. In this paper, we summarize the various imaging features of CSVD and discuss the correlation between amygdala changes and VCI. We also explore how new neuroimaging methods can assess amygdala changes early, laying a foundation for future comprehensive exploration of the pathogenesis of CSVD.
摘要：
脑小血管病（CSVD）是一种常见的血管性疾病，一直与血管性认知障碍（VCI）相关。CSVD的诊断仍然依赖于磁共振成像(MRI)。流行病学资料表明CSVD的特征性MRI特征,包括白质高强度（WMH）和腔隙性脑梗死，在社区研究中，40岁以上的人非常普遍。这种流行给许多低收入和中等收入家庭带来了沉重的负担。杏仁核在整合感觉和联想信息以调节情绪认知中起着至关重要的作用。尽管以前的许多研究已经将杏仁核的改变与各种疾病联系起来，比如抑郁症，由于CSVD的复杂性,关于CSVD相关杏仁核改变的研究很少.在本文中,我们总结了CSVD的各种影像学特征，并讨论了杏仁核变化与VCI的相关性。我们还探讨了新的神经成像方法如何早期评估杏仁核的变化，为今后全面探索CSVD的发病机制奠定基础。
