Abstract：
UNASSIGNED: Polyphenols are organic compounds with diverse biological activities such as anti-inflammatory and antioxidant effects, making them important candidates for the development of anti-aging drugs. In this systematic review, we aimed to answer the question: can plant-derived polyphenols have an immunomodulatory effect in experimental models of aging?
UNASSIGNED: We systematically searched Web of Science, MEDLINE/Pubmed, and Embase to select articles using the following combinations of terms and synonyms: polyphenols, phenols, senescence, aging, and immune. The selected articles were evaluated for reporting quality and risk-of-bias according to standard guidelines.
UNASSIGNED: The most used polyphenol was resveratrol, followed by curcumin, salidroside, and gallic acid. These molecules demonstrated an ability to restore immune function both in vitro and in vivo. The mechanism of action was not completely elucidated in these studies, but inhibition of NF-kB signaling, and antioxidant properties seemed to account for the anti-aging effects. All articles included in the review had good quality of reporting but failed to describe an adequate sample size, criteria for inclusion/exclusion, randomization, and blinding.
UNASSIGNED: We conclude that polyphenols are promising immunomodulatory substances for use in anti-aging therapies. However, more research with standardized analysis is needed to understand the role of these molecules in the prevention or reduction of damage associated with the aging process, as well as to determine the safety profile and consequences of systemic action.
UNASSIGNED: We systematically searched Web of Science, MEDLINE/Pubmed, and Embase to select articles using the following combinations of terms and synonyms: polyphenols, phenols, senescence, aging, and immune. The selected articles were evaluated for reporting quality and risk-of-bias according to standard guidelines.
UNASSIGNED: The most used polyphenol was resveratrol, followed by curcumin, salidroside, and gallic acid. These molecules demonstrated an ability to restore immune function both in vitro and in vivo. The mechanism of action was not completely elucidated in these studies, but inhibition of NF-kB signaling, and antioxidant properties seemed to account for the anti-aging effects. All articles included in the review had good quality of reporting but failed to describe an adequate sample size, criteria for inclusion/exclusion, randomization, and blinding.
UNASSIGNED: We conclude that polyphenols are promising immunomodulatory substances for use in anti-aging therapies. However, more research with standardized analysis is needed to understand the role of these molecules in the prevention or reduction of damage associated with the aging process, as well as to determine the safety profile and consequences of systemic action.
摘要：
■多酚是具有多种生物活性的有机化合物，例如抗炎和抗氧化作用，使它们成为开发抗衰老药物的重要候选人。在这次系统审查中，我们旨在回答这个问题：植物来源的多酚在衰老的实验模型中是否具有免疫调节作用？
■我们系统地搜索了WebofScience，MEDLINE/Pubmed,和Embase使用以下术语和同义词的组合来选择文章：多酚，酚类物质,衰老，老化，和免疫。根据标准指南对所选文章的报告质量和偏倚风险进行评估。
■最常用的多酚是白藜芦醇，其次是姜黄素,红景天苷,和没食子酸。这些分子表现出在体外和体内恢复免疫功能的能力。在这些研究中，作用机制没有完全阐明，但抑制NF-kB信号,和抗氧化特性似乎解释了抗衰老的作用。审查中包含的所有文章都具有良好的报告质量，但未能描述足够的样本量，纳入/排除标准，随机化，和致盲。
■我们得出结论，多酚是有希望用于抗衰老治疗的免疫调节物质。然而,需要进行更多的标准化分析研究，以了解这些分子在预防或减少与衰老过程相关的损害中的作用，以及确定系统行动的安全性和后果。
■我们系统地搜索了WebofScience，MEDLINE/Pubmed,和Embase使用以下术语和同义词的组合来选择文章：多酚，酚类物质,衰老，老化，和免疫。根据标准指南对所选文章的报告质量和偏倚风险进行评估。
■最常用的多酚是白藜芦醇，其次是姜黄素,红景天苷,和没食子酸。这些分子表现出在体外和体内恢复免疫功能的能力。在这些研究中，作用机制没有完全阐明，但抑制NF-kB信号,和抗氧化特性似乎解释了抗衰老的作用。审查中包含的所有文章都具有良好的报告质量，但未能描述足够的样本量，纳入/排除标准，随机化，和致盲。
■我们得出结论，多酚是有希望用于抗衰老治疗的免疫调节物质。然而,需要进行更多的标准化分析研究，以了解这些分子在预防或减少与衰老过程相关的损害中的作用，以及确定系统行动的安全性和后果。
