PDF(Pubmed)
Abstract：
UNASSIGNED: : There is a growing interest among clinicians and researchers in identifying potential biomarkers associated with autism. Neurofilament light chain (NfL) and Tau protein, which are proteins associated with neurodegeneration and neuroaxonal degeneration, are particularly promising potential biomarker candidates in this field.
UNASSIGNED: : In this study, we compared serum NfL (sNfL) and serum Tau (sTau) levels in Autism spectrum disorder (ASD) patients, their healthy siblings (HS), and healthy controls (HC), aimed to investigate their relationship with ASD severity. Our study included 43 ASD-diagnosed participants, 43 HS participants and 42 HC participants. Clinical characteristics of the participants were assesed by Kiddie Schedule for Affective Disorders and Schizophrenia, Childhood Autism Rating Scale, Aberrant Behavior Checklist, and Strengths and Difficulties Questionnaire. Serum samples were subjected to analysis via enzyme-linked immunosorbent assay to quantitatively measure the levels of NfL and Tau protein.
UNASSIGNED: : sNfL levels in the ASD group were significantly higher than both of the control groups. Regarding sTau levels, no significant difference was found between study and control groups. In addition, NfL and Tau levels were not significantly correlated with ASD symptom severity.
UNASSIGNED: : Our findings may indicate that the sNfl levels associated with neuroaxonal damage may constitue a potential clinical biomarker rather than being an endophenotype phenomena.
UNASSIGNED: : In this study, we compared serum NfL (sNfL) and serum Tau (sTau) levels in Autism spectrum disorder (ASD) patients, their healthy siblings (HS), and healthy controls (HC), aimed to investigate their relationship with ASD severity. Our study included 43 ASD-diagnosed participants, 43 HS participants and 42 HC participants. Clinical characteristics of the participants were assesed by Kiddie Schedule for Affective Disorders and Schizophrenia, Childhood Autism Rating Scale, Aberrant Behavior Checklist, and Strengths and Difficulties Questionnaire. Serum samples were subjected to analysis via enzyme-linked immunosorbent assay to quantitatively measure the levels of NfL and Tau protein.
UNASSIGNED: : sNfL levels in the ASD group were significantly higher than both of the control groups. Regarding sTau levels, no significant difference was found between study and control groups. In addition, NfL and Tau levels were not significantly correlated with ASD symptom severity.
UNASSIGNED: : Our findings may indicate that the sNfl levels associated with neuroaxonal damage may constitue a potential clinical biomarker rather than being an endophenotype phenomena.
摘要：
■：临床医生和研究人员对识别与自闭症相关的潜在生物标志物越来越感兴趣。神经丝轻链（NfL）和Tau蛋白，它们是与神经变性和神经轴突变性相关的蛋白质，是该领域特别有前途的潜在生物标志物候选物。
■：在这项研究中，我们比较了孤独症谱系障碍（ASD）患者的血清NfL（sNfL）和血清Tau（sTau）水平，他们健康的兄弟姐妹(HS)，和健康对照（HC），旨在调查它们与ASD严重程度的关系。我们的研究包括43名被诊断为ASD的参与者，43名HS参与者和42名HC参与者。参与者的临床特征通过Kiddie情感性疾病和精神分裂症时间表进行评估，儿童自闭症评定量表,异常行为清单,和优势和困难问卷。通过酶联免疫吸附测定对血清样品进行分析以定量测量NfL和Tau蛋白的水平。
■：ASD组的sNfL水平明显高于两个对照组。关于stau水平，研究组与对照组之间无显著差异.此外,NFL和Tau水平与ASD症状严重程度无显着相关。
■：我们的发现可能表明与神经轴突损伤相关的sNfl水平可能构成潜在的临床生物标志物，而不是内表型现象。
■：在这项研究中，我们比较了孤独症谱系障碍（ASD）患者的血清NfL（sNfL）和血清Tau（sTau）水平，他们健康的兄弟姐妹(HS)，和健康对照（HC），旨在调查它们与ASD严重程度的关系。我们的研究包括43名被诊断为ASD的参与者，43名HS参与者和42名HC参与者。参与者的临床特征通过Kiddie情感性疾病和精神分裂症时间表进行评估，儿童自闭症评定量表,异常行为清单,和优势和困难问卷。通过酶联免疫吸附测定对血清样品进行分析以定量测量NfL和Tau蛋白的水平。
■：ASD组的sNfL水平明显高于两个对照组。关于stau水平，研究组与对照组之间无显著差异.此外,NFL和Tau水平与ASD症状严重程度无显着相关。
■：我们的发现可能表明与神经轴突损伤相关的sNfl水平可能构成潜在的临床生物标志物，而不是内表型现象。
