PDF(Pubmed)
Abstract：
BACKGROUND: Osteogenesis imperfecta (OI) is an inherited disorder characterized by bone fragility and skeletal alterations. The administration of bisphosphonates (BPs) to patients with OI reduces pain, thereby improving their quality of life. The main mechanism of action of BPs is the inhibition of osteoclast action. In the oral cavity of children with OI during growth and development, physiological processes that require the function of osteoclasts occur. The aim of this investigation was to study the dental development of premolars and the root resorption of primary molars in children with OI medicated with BPs according to age and sex.
METHODS: An observational and analytical study was designed. The study sample consisted of 26 6- to 12-year-old children with a confirmed diagnosis of OI treated with BPs with available panoramic radiographs. The control group consisted of 395 children with available panoramic radiographs. Both groups were divided into subgroups according to sex and age. The third quadrant was studied, focusing on the first left temporary molar (7.4), the second left temporary molar (7.5), the first left permanent premolar (3.4) and the second left permanent premolar (3.5). The Demirjian method was used to study the dental development of 3.4 and 3.5, and the Haavikko method was used to study the root resorption of 7.4 and 7.5. The Mann‒Whitney U test was used for comparisons, and p < 0.05 indicated statistical significance.
RESULTS: The mean chronological age of the 421 patients was 9.21 years (95% CI 9.05-9.37). The sample was reasonably balanced by sex, with 52.5% (221 patients) boys versus 47.5% (200 patients) girls. Delayed exfoliation and tooth development were described in children with OI (p = 0.05). According to sex, the root resorption of primary molars and tooth development were significantly lower in boys in both groups and in girls in the OI group, but the differences between the age groups were not significant.
CONCLUSIONS: Children with OI treated with BPs exhibit delayed dental development of the premolars and delayed root resorption of the primary molars. Boys exhibited delays in both variables, but the differences by age subgroup were not significant. These clinical findings support the importance of clinically and radiographically monitoring the dental development and root resorption of primary teeth in children with OI treated with BPs to avoid alterations of the eruptive process.
METHODS: An observational and analytical study was designed. The study sample consisted of 26 6- to 12-year-old children with a confirmed diagnosis of OI treated with BPs with available panoramic radiographs. The control group consisted of 395 children with available panoramic radiographs. Both groups were divided into subgroups according to sex and age. The third quadrant was studied, focusing on the first left temporary molar (7.4), the second left temporary molar (7.5), the first left permanent premolar (3.4) and the second left permanent premolar (3.5). The Demirjian method was used to study the dental development of 3.4 and 3.5, and the Haavikko method was used to study the root resorption of 7.4 and 7.5. The Mann‒Whitney U test was used for comparisons, and p < 0.05 indicated statistical significance.
RESULTS: The mean chronological age of the 421 patients was 9.21 years (95% CI 9.05-9.37). The sample was reasonably balanced by sex, with 52.5% (221 patients) boys versus 47.5% (200 patients) girls. Delayed exfoliation and tooth development were described in children with OI (p = 0.05). According to sex, the root resorption of primary molars and tooth development were significantly lower in boys in both groups and in girls in the OI group, but the differences between the age groups were not significant.
CONCLUSIONS: Children with OI treated with BPs exhibit delayed dental development of the premolars and delayed root resorption of the primary molars. Boys exhibited delays in both variables, but the differences by age subgroup were not significant. These clinical findings support the importance of clinically and radiographically monitoring the dental development and root resorption of primary teeth in children with OI treated with BPs to avoid alterations of the eruptive process.
摘要：
背景：成骨不全症（OI）是一种以骨骼脆性和骨骼改变为特征的遗传性疾病。给予OI患者双膦酸盐（BPs）减轻疼痛，从而提高他们的生活质量。BPs的主要作用机制是抑制破骨细胞作用。在生长和发育过程中OI儿童的口腔中，需要破骨细胞功能的生理过程发生。这项调查的目的是根据年龄和性别研究OI加药BP的儿童的前磨牙的牙齿发育和原发性磨牙的牙根吸收。
方法：设计了一项观察性和分析性研究。研究样本包括26名6至12岁的儿童，这些儿童被确诊为OI，并使用BP进行了全景X光片治疗。对照组由395名具有全景X射线照片的儿童组成。根据性别和年龄将两组分为亚组。研究了第三象限，专注于第一个左临时磨牙（7.4），第二个左临时磨牙（7.5），第一左恒前磨牙（3.4）和第二左恒前磨牙（3.5）。Demirjian方法用于研究3.4和3.5的牙齿发育，Haavikko方法用于研究7.4和7.5的牙根吸收。Mann-WhitneyU检验用于比较，P<0.05表示有统计学意义。
结果：421例患者的平均实际年龄为9.21岁（95％CI9.05-9.37）。样本按性别合理平衡，有52.5%（221例）男孩和47.5%（200例）女孩。OI儿童的剥脱和牙齿发育延迟（p=0.05）。根据性别，两个组的男孩和OI组的女孩的原发性磨牙的根吸收和牙齿发育均显着降低，但各年龄组间差异不显著.
结论：接受BPs治疗的OI患儿表现出前磨牙发育延迟和原磨牙牙根吸收延迟。男孩在两个变量中都表现出延迟，但各年龄亚组差异不显著。这些临床发现支持临床和影像学监测BPs治疗OI儿童牙齿发育和牙根吸收的重要性，以避免喷发过程的改变。
方法：设计了一项观察性和分析性研究。研究样本包括26名6至12岁的儿童，这些儿童被确诊为OI，并使用BP进行了全景X光片治疗。对照组由395名具有全景X射线照片的儿童组成。根据性别和年龄将两组分为亚组。研究了第三象限，专注于第一个左临时磨牙（7.4），第二个左临时磨牙（7.5），第一左恒前磨牙（3.4）和第二左恒前磨牙（3.5）。Demirjian方法用于研究3.4和3.5的牙齿发育，Haavikko方法用于研究7.4和7.5的牙根吸收。Mann-WhitneyU检验用于比较，P<0.05表示有统计学意义。
结果：421例患者的平均实际年龄为9.21岁（95％CI9.05-9.37）。样本按性别合理平衡，有52.5%（221例）男孩和47.5%（200例）女孩。OI儿童的剥脱和牙齿发育延迟（p=0.05）。根据性别，两个组的男孩和OI组的女孩的原发性磨牙的根吸收和牙齿发育均显着降低，但各年龄组间差异不显著.
结论：接受BPs治疗的OI患儿表现出前磨牙发育延迟和原磨牙牙根吸收延迟。男孩在两个变量中都表现出延迟，但各年龄亚组差异不显著。这些临床发现支持临床和影像学监测BPs治疗OI儿童牙齿发育和牙根吸收的重要性，以避免喷发过程的改变。
