PDF(Pubmed)
Abstract：
Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells is intricately linked to protein synthesis, nucleotide synthesis, modulation of signaling pathways, regulation of tumor cell metabolism, maintenance of oxidative stress homeostasis, and epigenetic modifications. Furthermore, the dysregulation of amino acid metabolism also impacts tumor microenvironment and tumor immunity. Amino acids can act as signaling molecules that modulate immune cell function and immune tolerance within the tumor microenvironment, reshaping the anti-tumor immune response and promoting immune evasion by cancer cells. Moreover, amino acid metabolism can influence the behavior of stromal cells, such as cancer-associated fibroblasts, regulate ECM remodeling and promote angiogenesis, thereby facilitating tumor growth and metastasis. Understanding the intricate interplay between amino acid metabolism and the tumor microenvironment is of crucial significance. Expanding our knowledge of the multifaceted roles of amino acid metabolism in tumor microenvironment holds significant promise for the development of more effective cancer therapies aimed at disrupting the metabolic dependencies of cancer cells and modulating the tumor microenvironment to enhance anti-tumor immune responses and inhibit tumor progression.
摘要：
氨基酸代谢在肿瘤微环境中起着举足轻重的作用,影响癌症进展的各个方面。肿瘤细胞中氨基酸的代谢重编程与蛋白质合成密切相关，核苷酸合成，信号通路的调节，肿瘤细胞代谢的调节，维持氧化应激稳态，和表观遗传修饰。此外，氨基酸代谢失调也会影响肿瘤微环境和肿瘤免疫。氨基酸可以作为信号分子，调节肿瘤微环境中的免疫细胞功能和免疫耐受，重塑抗肿瘤免疫反应，促进癌细胞的免疫逃避。此外，氨基酸代谢可以影响基质细胞的行为，如癌症相关的成纤维细胞，调节ECM重塑和促进血管生成，从而促进肿瘤生长和转移。了解氨基酸代谢与肿瘤微环境之间的复杂相互作用至关重要。扩大我们对氨基酸代谢在肿瘤微环境中的多方面作用的认识，对于开发更有效的癌症疗法具有重要的前景，旨在破坏癌细胞的代谢依赖性并调节肿瘤微环境以增强抗肿瘤免疫反应并抑制肿瘤进展。
