关键词: cervical cancer eIF4A eIF4E papillomavirus translational control

Mesh : Humans Protein Biosynthesis RNA, Messenger / genetics metabolism Papillomaviridae Oncogene Proteins, Viral / metabolism genetics Papillomavirus Infections / virology RNA, Viral / genetics metabolism Uterine Cervical Neoplasms / virology metabolism genetics Gene Expression Regulation, Viral Female

来  源:   DOI:10.1016/j.tcb.2024.07.001

Abstract:
High-risk human papillomaviruses (HPVs) cause most cases of cervical cancer, a disease with an increasing impact worldwide. Recent studies have shown that the synthesis of viral oncoproteins is strongly subject to translational control. Thus, targeting the protein synthesis machinery might open novel avenues to develop innovative therapies aiming to improve patients\' survival.
摘要:
高危型人乳头瘤病毒(HPV)导致大多数宫颈癌,一种在世界范围内影响越来越大的疾病。最近的研究表明,病毒癌蛋白的合成强烈受到翻译控制。因此,靶向蛋白质合成机制可能为开发旨在提高患者生存率的创新疗法开辟新的途径。
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