Abstract：
BACKGROUND: Internal tremors and vibrations are symptoms previously described as part of neurologic disorders but not fully described as a part of long COVID. This study compared pre-pandemic comorbidities, new-onset conditions, and long COVID symptoms between people with internal tremors and vibrations as part of their long COVID symptoms and people with long COVID but without these symptoms.
METHODS: The Yale Listen to Immune, Symptom and Treatment Experiences Now (LISTEN) Study surveyed 423 adults who had long COVID between May 12, 2022 and June 1, 2023. The exposure variable was long COVID symptoms of internal tremors and vibrations. The outcome variables were demographic characteristics, pre-pandemic comorbidities, new-onset conditions, other symptoms, and quality of life.
RESULTS: Among study participants with long COVID, median age was 46 years [IQR, 38-56]), 74% were female, 87% were Non-Hispanic White, and 158 (37%) reported \"internal tremors, or buzzing/vibration\" as a long COVID symptom. The 2 groups reported similar pre-pandemic comorbidities, but people with internal tremors reported worse health as measured by the Euro-QoL visual analogue scale (median: 40 points [IQR, 30-60] vs. 50 points [IQR, 35-62], P = 0.007) and had higher rates of new-onset mast cell disorders (11% [95% CI, 7.1-18] vs. 2.6% [1.2-5.6], P = 0.008) and neurologic conditions (22% [95% CI, 16-29] vs. 8.3% [5.4-12], P = 0.004).
CONCLUSIONS: Among people with long COVID, those with internal tremors and vibrations had different conditions and symptoms and worse health status compared with others who had long COVID without these symptoms.
METHODS: The Yale Listen to Immune, Symptom and Treatment Experiences Now (LISTEN) Study surveyed 423 adults who had long COVID between May 12, 2022 and June 1, 2023. The exposure variable was long COVID symptoms of internal tremors and vibrations. The outcome variables were demographic characteristics, pre-pandemic comorbidities, new-onset conditions, other symptoms, and quality of life.
RESULTS: Among study participants with long COVID, median age was 46 years [IQR, 38-56]), 74% were female, 87% were Non-Hispanic White, and 158 (37%) reported \"internal tremors, or buzzing/vibration\" as a long COVID symptom. The 2 groups reported similar pre-pandemic comorbidities, but people with internal tremors reported worse health as measured by the Euro-QoL visual analogue scale (median: 40 points [IQR, 30-60] vs. 50 points [IQR, 35-62], P = 0.007) and had higher rates of new-onset mast cell disorders (11% [95% CI, 7.1-18] vs. 2.6% [1.2-5.6], P = 0.008) and neurologic conditions (22% [95% CI, 16-29] vs. 8.3% [5.4-12], P = 0.004).
CONCLUSIONS: Among people with long COVID, those with internal tremors and vibrations had different conditions and symptoms and worse health status compared with others who had long COVID without these symptoms.
摘要：
背景：内部震颤和振动是先前描述为神经系统疾病的一部分的症状，但未完全描述为长COVID的一部分。这项研究比较了大流行前的合并症，新的发病条件，以及长期COVID症状，存在于长期COVID症状的患者和长期COVID但没有这些症状的患者之间。
方法：耶鲁听免疫，现在的症状和治疗经验（LISTEN）研究调查了2022年5月12日至2023年6月1日期间患有长期COVID的423名成年人。暴露变量是内部震颤和振动的长期COVID症状。结果变量是人口统计学特征，大流行前的合并症，新的发病条件，其他症状,和生活质量。
结果：在长期COVID的研究参与者中，中位年龄为46岁[IQR，38-56]),74%是女性，87%是非西班牙裔白人，158（37%）报告了“内部震颤”，或嗡嗡声/振动“作为长时间的COVID症状。两组报告了类似的大流行前合并症，但是，根据Euro-QoL视觉模拟量表（中位数：40分[IQR，30-60]vs.50分[IQR，35-62],P=0.007），并且新发肥大细胞疾病的发生率更高（11％[95％CI，7.1-18]与2.6%[1.2-5.6]，P=0.008）和神经系统状况（22%[95%CI，16-29]与8.3%[5.4-12]，P=0.004)。
结论：在长期COVID患者中，与那些长期患有COVID而没有这些症状的人相比，那些有内部震颤和振动的人有不同的病情和症状，健康状况更差。
方法：耶鲁听免疫，现在的症状和治疗经验（LISTEN）研究调查了2022年5月12日至2023年6月1日期间患有长期COVID的423名成年人。暴露变量是内部震颤和振动的长期COVID症状。结果变量是人口统计学特征，大流行前的合并症，新的发病条件，其他症状,和生活质量。
结果：在长期COVID的研究参与者中，中位年龄为46岁[IQR，38-56]),74%是女性，87%是非西班牙裔白人，158（37%）报告了“内部震颤”，或嗡嗡声/振动“作为长时间的COVID症状。两组报告了类似的大流行前合并症，但是，根据Euro-QoL视觉模拟量表（中位数：40分[IQR，30-60]vs.50分[IQR，35-62],P=0.007），并且新发肥大细胞疾病的发生率更高（11％[95％CI，7.1-18]与2.6%[1.2-5.6]，P=0.008）和神经系统状况（22%[95%CI，16-29]与8.3%[5.4-12]，P=0.004)。
结论：在长期COVID患者中，与那些长期患有COVID而没有这些症状的人相比，那些有内部震颤和振动的人有不同的病情和症状，健康状况更差。
