Abstract：
OBJECTIVE: A novel Cone-Beam Computed Tomography (CBCT) named HyperSight provides superior CBCT image quality compared to conventional ring gantry CBCT imaging, and it is suitable for dose calculations for prostate cancer, but it comes with considerable additional costs. The aim of this study was to determine the added value of HyperSight CBCT imaging compared to conventional CBCT imaging in terms of organ visibility in the male pelvic region.
METHODS: Twenty prostate cancer patients were included in this prospective clinical study. For each patient three CBCT pairs, consisting of HyperSight and conventional CBCT scans acquired on consecutive days, were included. CBCT scans were evaluated by four observers in terms of visibility of the prostate, bladder, rectum and seminal vesicles. Visibility was scored on a 1-to-5 scale and by annotating axial slices where the organs were hard to delineate. Lastly, observers indicated whether the CBCT scans were of sufficient quality for an online adaptive radiation therapy workflow.
RESULTS: All four organs were better visible on HyperSight CBCT scans compared to conventional CBCT scans. The mean visibility scores increased from 3.1 to 4.5 on a 1--5 scale of and the mean number of annotated slices reduced from 4.5 to 1.1. 99% Of the HyperSight CBCT scans were considered suitable for an online adaptive workflow vs 25-83% for the conventional CBCT scans.
CONCLUSIONS: HyperSight CBCT scans yielded a visibility of prostate, bladder, rectum and seminal vesicles comparable to planning CT scans and, can replace a repeat planning CT scan in case of anatomical changes requiring a new treatment plan.
METHODS: Twenty prostate cancer patients were included in this prospective clinical study. For each patient three CBCT pairs, consisting of HyperSight and conventional CBCT scans acquired on consecutive days, were included. CBCT scans were evaluated by four observers in terms of visibility of the prostate, bladder, rectum and seminal vesicles. Visibility was scored on a 1-to-5 scale and by annotating axial slices where the organs were hard to delineate. Lastly, observers indicated whether the CBCT scans were of sufficient quality for an online adaptive radiation therapy workflow.
RESULTS: All four organs were better visible on HyperSight CBCT scans compared to conventional CBCT scans. The mean visibility scores increased from 3.1 to 4.5 on a 1--5 scale of and the mean number of annotated slices reduced from 4.5 to 1.1. 99% Of the HyperSight CBCT scans were considered suitable for an online adaptive workflow vs 25-83% for the conventional CBCT scans.
CONCLUSIONS: HyperSight CBCT scans yielded a visibility of prostate, bladder, rectum and seminal vesicles comparable to planning CT scans and, can replace a repeat planning CT scan in case of anatomical changes requiring a new treatment plan.
摘要：
目的：一种名为HyperSight的新型锥束计算机断层扫描（CBCT）与传统的环形机架CBCT成像相比，具有出色的CBCT图像质量，它适用于前列腺癌的剂量计算，但它带来了相当大的额外成本。这项研究的目的是确定与传统CBCT成像相比，HyperSightCBCT成像在男性骨盆区域器官可见性方面的附加值。
方法：本前瞻性临床研究纳入了20例前列腺癌患者。每个病人有三对CBCT,由连续几天获得的HyperSight和常规CBCT扫描组成，包括在内。CBCT扫描由四名观察者评估前列腺的可见度，膀胱,直肠和精囊。以1至5的标度并通过注释难以描绘器官的轴向切片来对可见性进行评分。最后,观察者指出,CBCT扫描的质量是否足以满足在线自适应放射治疗工作流程的要求.
结果：与常规CBCT扫描相比，在HyperSightCBCT扫描中所有四个器官的可见性更好。在1-5量表上，平均可见性得分从3.1增加到4.5，注释切片的平均数量从4.5减少到1.1。99％的HyperSightCBCT扫描被认为适合于在线自适应工作流程，而常规CBCT扫描则为25-83％。
结论：HyperSightCBCT扫描显示了前列腺的可见性，膀胱,直肠和精囊与计划CT扫描相当，在需要新治疗计划的解剖变化的情况下，ccan替换重复计划CT扫描。
方法：本前瞻性临床研究纳入了20例前列腺癌患者。每个病人有三对CBCT,由连续几天获得的HyperSight和常规CBCT扫描组成，包括在内。CBCT扫描由四名观察者评估前列腺的可见度，膀胱,直肠和精囊。以1至5的标度并通过注释难以描绘器官的轴向切片来对可见性进行评分。最后,观察者指出,CBCT扫描的质量是否足以满足在线自适应放射治疗工作流程的要求.
结果：与常规CBCT扫描相比，在HyperSightCBCT扫描中所有四个器官的可见性更好。在1-5量表上，平均可见性得分从3.1增加到4.5，注释切片的平均数量从4.5减少到1.1。99％的HyperSightCBCT扫描被认为适合于在线自适应工作流程，而常规CBCT扫描则为25-83％。
结论：HyperSightCBCT扫描显示了前列腺的可见性，膀胱,直肠和精囊与计划CT扫描相当，在需要新治疗计划的解剖变化的情况下，ccan替换重复计划CT扫描。
