Abstract：
Ovarian cancer is one of the most common gynecologic malignancies. Recurrence and metastasis often occur after treatment, and it has the highest mortality rate of all gynecological tumors. Cancer stem cells (CSCs) are a small population of cells with the ability of self-renewal, multidirectional differentiation, and infinite proliferation. They have been shown to play an important role in tumor growth, metastasis, drug resistance, and angiogenesis. Ovarian cancer side population (SP) cells, a type of CSC, have been shown to play roles in tumor formation, colony formation, xenograft tumor formation, ascites formation, and tumor metastasis. The rapid progression of tumor angiogenesis is necessary for tumor growth; however, many of the mechanisms driving this process are unclear as is the contribution of CSCs. The aim of this review was to document the current state of knowledge of the molecular mechanism of ovarian cancer stem cells (OCSCs) in regulating tumor angiogenesis.
摘要：
卵巢癌是妇科最常见的恶性肿瘤之一。复发和转移常发生在治疗后，在所有妇科肿瘤中死亡率最高。肿瘤干细胞(CSC)是具有自我更新能力的小细胞群,多向分化，无限扩散。它们已被证明在肿瘤生长中起重要作用，转移,耐药性,和血管生成。卵巢癌侧群（SP）细胞，一种CSC，已被证明在肿瘤形成中起作用，菌落形成,异种移植瘤形成，腹水形成,和肿瘤转移。肿瘤血管生成的快速进展是肿瘤生长所必需的；然而，驱动这一过程的许多机制尚不清楚,CSC的贡献也不清楚.这篇综述的目的是记录有关卵巢癌干细胞（OCSCs）调节肿瘤血管生成的分子机制的最新知识。
