Abstract：
Malignant melanoma (MM) is a highly invasive and therapeutically resistant skin malignancy, posing a significant clinical challenge in its treatment. Programmed cell death plays a crucial role in the occurrence and progression of MM. Sphingolipids (SP), as a class of bioactive lipids, may be associated with many kinds of diseases. SPs regulate various forms of programmed cell death in tumors, including apoptosis, necroptosis, ferroptosis, and more. This review will delve into the mechanisms by which different types of SPs modulate various forms of programmed cell death in MM, such as their regulation of cell membrane permeability and signaling pathways, and how they influence the survival and death fate of MM cells. An in-depth exploration of the role of SPs in programmed cell death in MM aids in unraveling the molecular mechanisms of melanoma development and holds significant importance in developing novel therapeutic strategies.
摘要：
恶性黑色素瘤(MM)是一种具有高度侵袭性和治疗抗性的皮肤恶性肿瘤,对其治疗构成了重大的临床挑战。细胞程序性死亡在MM的发生和发展中起着至关重要的作用。鞘脂（SP），作为一类生物活性脂质，可能与多种疾病相关。SP调节肿瘤中各种形式的程序性细胞死亡，包括细胞凋亡,坏死,铁性凋亡,还有更多.这篇综述将深入研究不同类型的SP调节MM中各种形式的程序性细胞死亡的机制。如它们对细胞膜通透性和信号通路的调节，以及它们如何影响MM细胞的生存和死亡命运。对SP在MM中程序性细胞死亡中的作用的深入探索有助于揭示黑色素瘤发展的分子机制，并在开发新的治疗策略中具有重要意义。
