Abstract：
Patients with hemophilia frequently require supplementary interventions, either invasive (suturing, gel foam, or cauterization) or non-invasive (fibrin sealant/glue), to attain hemostasis post dental procedures. This study aimed to compare the efficacy of fibrin sealant against traditional methods for achieving hemostasis post dental surgery. The medical records of patients with factor VIII or IX deficiency, or von Willebrand disease, who underwent dental procedures in the Department of Dentistry, Seth GSMC and KEM Hospital, were evaluated for inclusion in this retrospective matched cohort study. Cohort-1 included those treated with a fibrin sealant (Tisseel Lyo) with/without traditional hemostatic measures post-procedure, while cohort-2 (controls) included those in whom no fibrin sealant was used. A total of 128 patients, 64 in each group, were evaluated. There was no statistically significant difference in demographics, disease-related variables, dental complaints, or preoperative treatment given between the groups. However, there was a significant reduction (P < 0.001) in the requirement for secondary procedures for hemostasis (suturing, gel foam application, and/or cauterization) and postoperative requirement for factor replacement (P = 0.003) in the fibrin glue group as compared to the controls. In this study, fibrin sealant demonstrated superior efficacy in mitigating the necessity for active hemostasis control.
摘要：
血友病患者经常需要补充干预措施，要么是侵入性的(缝合，凝胶泡沫，或烧灼）或非侵入性（纤维蛋白密封剂/胶水），在牙科手术后实现止血。这项研究旨在比较纤维蛋白密封剂与传统方法在牙科手术后实现止血的功效。因子VIII或IX缺乏症患者的医疗记录，或者vonWillebrand病,他在牙科部门接受了牙科手术，SethGSMC和KEM医院，在这项回顾性配对队列研究中进行了纳入评估。队列1包括使用纤维蛋白密封剂（TisseelLyo）治疗的患者，术后有/没有传统的止血措施，而队列2（对照）包括未使用纤维蛋白密封剂的患者。共有128名患者，每组64人，进行了评估。人口统计学差异无统计学意义，疾病相关变量，牙科投诉,或组间给予术前治疗。然而,止血的二次手术（缝合，凝胶泡沫应用，和/或烧灼）和与对照组相比，纤维蛋白胶组的术后因素置换需求（P=0.003）。在这项研究中,纤维蛋白密封剂在减轻主动止血控制的必要性方面表现出优异的功效。
