Abstract:
The history of intestinal transplantation can be traced back to the turn of the twentieth century. Although advancements have been made, the intestine still presents a greater challenge to transplantation than does that of other solid organs, experiencing higher rates of graft rejection and lower long-term survival. Increasingly, intestinal re-transplantation (re-ITx) is seen as a viable option and is now the fourth most common indication for ITx. Changes to immunosuppression protocols, technical modifications, and infectious disease monitoring have contributed to improved outcomes. The authors review the literature on re-ITx in regard to the history, management considerations, and future directions.
摘要:
肠道移植的历史可以追溯到20世纪初。虽然取得了进展,与其他实体器官相比,肠道仍然对移植提出了更大的挑战,经历较高的移植排斥率和较低的长期生存率。越来越多,肠道再移植(re-ITx)被认为是一种可行的选择,现在是ITx的第四大适应症.改变免疫抑制方案,技术修改,和传染病监测有助于改善结果。作者回顾了关于re-ITx的历史文献,管理方面的考虑,和未来的方向。