Abstract：
Long-duration spaceflight (LDSF) is associated with unique hazards and linked with numerous human health risks including Spaceflight Associated Neuro-ocular Syndrome (SANS). The proposed mechanisms for SANS include microgravity induced cephalad fluid shift and increased Intracranial Pressure (ICP). SANS is a disorder seen only after LDSF and has no direct terrestrial pathologic counterpart as the zero G environment cannot be completely replicated on Earth. Head-down tilt, bed rest studies however have been used as a terrestrial analog and produce the cephalad fluid shift. Some proposed countermeasures for SANS include vasoconstrictive thigh cuffs and lower body negative pressure. Another potential researched countermeasure is the impedance threshold device (ITD) which can reduce ICP. We review the mechanisms of the ITD and its potential use as a countermeasure for SANS.
摘要：
长期太空飞行（LDSF）与独特的危害有关，并与许多人类健康风险有关，包括太空飞行相关的神经眼综合症（SANS）。SANS的拟议机制包括微重力引起的头颅液移位和颅内压升高（ICP）。SANS是一种仅在LDSF之后出现的疾病，并且没有直接的地面病理对应物，因为零G环境无法在地球上完全复制。头向下倾斜,然而，卧床休息研究已被用作地面类似物，并产生头颅液移位。SANS的一些建议的对策包括血管收缩大腿袖口和下体负压。另一个潜在的研究对策是可以降低ICP的阻抗阈值器件（ITD）。我们回顾了ITD的机制及其作为SANS对策的潜在用途。
