METHODS: The study is designed as a cross-sectional online anonymous survey. The survey presents different scenarios to respondents relating to varying target differences and probability thresholds and explores success and futility criteria for clinical trials. The survey was developed with personal and public involvement (PPI) through focus groups and a PPI partner. Eligible participants will be those with a personal history of miscarriage, including partners, and healthcare professionals who manage patients who experience a miscarriage. Convenience, snowball and purposive sampling techniques will be employed to invite eligible participants to complete the survey. The survey will be accepting responses for an initial 2-week pilot to check validity, prior to being open for a further 12 weeks. Descriptive analyses and linear regression analyses will synthesise the survey results.
BACKGROUND: Ethical approval was obtained from the NHS Research Ethics Committee North West-Greater Manchester East (23/NW/0322) on 30 January 2024. Informed consent will be obtained prior to survey completion. No personal identifying information will be collected. The results will be published in a relevant scientific journal and communicated through our institutional website.
方法:该研究设计为横断面在线匿名调查。该调查向受访者提出了与不同的目标差异和概率阈值有关的不同情景,并探讨了临床试验的成功和无效标准。该调查是通过焦点小组和PPI合作伙伴在个人和公众参与(PPI)的情况下进行的。符合条件的参与者将是那些有个人流产史的人,包括合伙人,以及管理流产患者的医疗保健专业人员。方便,将采用滚雪球和目的性抽样技术邀请符合条件的参与者完成调查。该调查将接受最初为期2周的试点的回应,以检查有效性,在进一步开放12周之前。描述性分析和线性回归分析将综合调查结果。
背景:在2024年1月30日获得了NHS研究伦理委员会西北-大曼彻斯特东部(23/NW/0322)的伦理批准。调查完成前将获得知情同意。不会收集个人识别信息。研究结果将发表在相关科学杂志上,并通过我们的机构网站进行交流。