Abstract：
Bisphenols, parabens, and triclosan (TCS) are common endocrine disrupters used in various consumer products. These chemicals have been shown to cross the placental barrier and affect intrauterine development of fetuses. In this study, we quantified serum levels of six bisphenols, five parabens, and TCS in 483 pregnant women from southern China. Quantile-based g-computation showed that combined exposure to bisphenols, parabens, and TCS was significantly (p < 0.05) and negatively associated with birth weight (β = -39.9, 95% CI: -73.8, -6.1), birth length (β = -0.19, 95% CI: -0.34, -0.04), head circumference (β = -0.13, 95% CI: -0.24, -0.02), and thoracic circumference (β = -0.16, 95% CI: -0.29, -0.04). An inverse correlation was also identified between mixture exposure and gestational age (β = -0.12, 95% CI: -0.24, -0.01). Bisphenol A (BPA), bisphenol Z (BPZ), bisphenol AP (BPAP), propylparaben (PrP), and TCS served as the dominant contributors to the overall effect. In subgroup analyses, male newborns were more susceptible to mixture exposure than females, whereas the exposure-outcome link was prominent among pregnant women in the first and second trimesters. More evidence is warranted to elucidate the impacts of exposure to mixtures on birth outcomes, as well as the underlying mechanisms.
摘要：
双酚,对羟基苯甲酸酯,和三氯生（TCS）是各种消费品中使用的常见内分泌干扰物。已显示这些化学物质穿过胎盘屏障并影响胎儿的宫内发育。在这项研究中,我们量化了六种双酚的血清水平，五个对羟基苯甲酸酯,来自中国南方的483名孕妇和TCS。基于分位数的g计算表明，联合暴露于双酚，对羟基苯甲酸酯,TCS与出生体重呈显著负相关(P<0.05)(β=-39.9,95%CI:-73.8,-6.1),出生身长（β=-0.19，95%CI：-0.34，-0.04），头围（β=-0.13，95%CI：-0.24，-0.02），胸围（β=-0.16，95%CI：-0.29，-0.04）。混合物暴露与胎龄之间也存在负相关（β=-0.12，95％CI：-0.24，-0.01）。双酚A(BPA),双酚Z(BPZ),双酚AP（BPAP），对羟基苯甲酸丙酯（PrP），TCS是整体效应的主要贡献者。在亚组分析中，男性新生儿比女性更容易接触混合物，而在妊娠早期和中期的孕妇中,暴露与结局的联系显著.更多的证据是必要的，以阐明暴露于混合物对出生结果的影响，以及潜在的机制。
