PDF(Pubmed)
Abstract：
Anatomically connected bones and muscles determine movement of the body. Forces exerted on muscles are then turned to bones to promote osteogenesis. The crosstalk between muscle and bone has been identified as mechanotransduction previously. In addition to the mechanical features, bones and muscles are also secretory organs which interact closely with one another through producing myokines and osteokines. Moreover, besides the mechanical features, other factors, such as nutrition metabolism, physiological rhythm, age, etc., also affect bone-muscle crosstalk. What\'s more, osteogenesis and myogenesis within motor system occur almost in parallel. Pathologically, defective muscles are always detected in bone associated diseases and induce the osteopenia, inflammation and abnormal bone metabolism, etc., through biomechanical or biochemical coupling. Hence, we summarize the study findings of bone-muscle crosstalk and propose potential strategies to improve the skeletal or muscular symptoms of certain diseases. Altogether, functional improvement of bones or muscles is beneficial to each other within motor system.
摘要：
解剖连接的骨骼和肌肉决定了身体的运动。施加在肌肉上的力然后转向骨骼以促进骨生成。肌肉和骨骼之间的串扰以前已被确定为机械传导。除了机械功能，骨骼和肌肉也是分泌器官，它们通过产生肌细胞和骨细胞而彼此紧密地相互作用。此外，除了机械特征，其他因素,比如营养代谢，生理节律,年龄,等。,也影响骨-肌肉串扰。更重要的是，运动系统内的成骨和成肌几乎平行发生。病理上,在骨骼相关疾病中总是检测到有缺陷的肌肉，并导致骨质减少，炎症和骨代谢异常，等。,通过生物力学或生化耦合。因此，我们总结了骨-肌肉串扰的研究结果，并提出了改善某些疾病的骨骼或肌肉症状的潜在策略。总之,骨骼或肌肉的功能改善对运动系统内的彼此有益。
