PDF(Pubmed)
Abstract：
Allergic diseases affect up to 40% of the global population with a substantial rise in food allergies, in particular, over the past decades. For the majority of individuals with allergy fundamental programming of a pro-allergic immune system largely occurs in early childhood where it is crucially governed by prenatal genetic and environmental factors, including their interactions. These factors include several genetic aberrations, such as filaggrin loss-of-function mutations, early exposure to respiratory syncytial virus, and various chemicals such as plasticizers, as well as the influence of the gut microbiome and numerous lifestyle circumstances. The effects of such a wide range of factors on allergic responses to an array of potential allergens is complex and the severity of these responses in a clinical setting are subsequently not easy to predict at the present time. However, some parameters which condition a pro-allergic immune response, including severe anaphylaxis, are becoming clearer. This review summarises what we currently know, and don\'t know, about the factors which influence developing pro-allergic immunity particularly during the early-life perinatal period.
摘要：
过敏性疾病影响了全球40％的人口，食物过敏的数量大幅增加，特别是,在过去的几十年里。对于大多数患有致敏免疫系统的过敏基本程序的个体来说，主要发生在儿童早期，在那里它受到产前遗传和环境因素的关键控制。包括他们的互动。这些因素包括几种遗传畸变，例如聚丝团功能丧失突变，早期接触呼吸道合胞病毒，和各种化学物质，如增塑剂，以及肠道微生物组和许多生活方式的影响。如此广泛的因素对对一系列潜在变应原的变态反应的影响是复杂的,并且这些反应在临床环境中的严重程度目前不容易预测。然而,一些参数会影响过敏的免疫反应，包括严重的过敏反应,变得越来越清晰。这篇综述总结了我们目前所知道的，不知道，关于影响发展促过敏免疫的因素，特别是在生命早期围产期。
