PDF(Pubmed)
Abstract：
Tuberculosis (TB) remains a global health threat, necessitating innovative strategies for control and prevention. This comprehensive review explores the Mycobacterium tuberculosis Lysine Exporter (LysE) gene, unveiling its multifaceted roles and potential uses in controlling and preventing tuberculosis (TB). As a pivotal player in eliminating excess L-lysine and L-arginine, LysE contributes to the survival and virulence of M. tuberculosis. This review synthesizes findings from different electronic databases and includes 13 studies focused on the LysE of M. tuberculosis. The research unveils that LysE can be a potential drug target, a diagnostic marker for TB, and a promising candidate for vaccine development. The absence of LysE in the widely used BCG vaccine underscores its uniqueness and positions it as a novel area for TB prevention. In conclusion, this review underscores the significance of LysE in TB pathogenesis and its potential as a drug target, diagnostic marker, and vaccine candidate. The multifaceted nature of LysE positions it at the forefront of innovative approaches to combat TB, calling for sustained research efforts to harness its full potential in the global fight against this infectious disease.
摘要：
结核病（TB）仍然是全球健康威胁，需要创新的控制和预防战略。这篇全面的综述探讨了结核分枝杆菌赖氨酸转运蛋白（LysE）基因，揭示其在控制和预防结核病（TB）方面的多方面作用和潜在用途。作为消除过量L-赖氨酸和L-精氨酸的关键角色，LysE有助于结核分枝杆菌的存活和毒力。这篇综述综合了来自不同电子数据库的发现，包括13项针对结核分枝杆菌LysE的研究。这项研究揭示了LysE可以成为潜在的药物靶标，结核病的诊断标记，和疫苗开发的有希望的候选人。广泛使用的BCG疫苗中不存在LysE强调了其独特性，并将其定位为结核病预防的新领域。总之,这篇综述强调了LysE在结核病发病机制中的重要性及其作为药物靶标的潜力，诊断标记,和候选疫苗。LysE的多面性使其处于抗击结核病的创新方法的最前沿，呼吁持续的研究努力，以充分发挥其在全球抗击这种传染病的潜力。
