PDF(Pubmed)
Abstract：
COVID-19, generated by SARS-CoV-2, has significantly affected healthcare systems worldwide. The epidemic has highlighted the urgent need for vaccine development. Besides the conventional vaccination models, which include live-attenuated, recombinant protein, and inactivated vaccines, nanovaccines present a distinct opportunity to progress vaccine research and offer convenient alternatives. This review highlights the many widely used nanoparticle vaccine vectors, outlines their benefits and drawbacks, and examines recent developments in nanoparticle vaccines to prevent SARS-CoV-2. It also offers a thorough overview of the many advantages of nanoparticle vaccines, including an enhanced host immune response, multivalent antigen delivery, and efficient drug delivery. The main objective is to provide a reference for the development of innovative antiviral vaccines.
摘要：
由SARS-CoV-2产生的COVID-19已经严重影响了全球的医疗保健系统。这一流行病凸显了疫苗开发的迫切需要。除了传统的疫苗接种模型，其中包括活减毒，重组蛋白，和灭活疫苗，纳米疫苗为推进疫苗研究和提供方便的替代品提供了一个独特的机会。这篇综述重点介绍了许多广泛使用的纳米颗粒疫苗载体，概述了它们的优点和缺点，并研究了预防SARS-CoV-2的纳米颗粒疫苗的最新进展。它还全面概述了纳米颗粒疫苗的许多优点，包括增强的宿主免疫反应，多价抗原递送，和有效的药物输送。主要目的是为创新抗病毒疫苗的开发提供参考。
