溶瘤禽呼肠孤病毒 p17 蛋白通过抑制 FAK / Src 通路和 TKs5 / NCK1 复合物的形成来抑制小鼠黑色素瘤细胞中 Invadopodia 的形成。
关键词: FAK/Src MMP9 Rab40b TKs5/NCK1 complex avian reoviruses invadopodia p17 p53/PTEN
Mesh : Animals Mice Orthoreovirus, Avian / physiology genetics Cell Line, Tumor Signal Transduction Podosomes / metabolism Cell Movement Focal Adhesion Kinase 1 / metabolism genetics Adaptor Proteins, Signal Transducing / metabolism genetics Oncolytic Viruses / physiology genetics src-Family Kinases / metabolism genetics Viral Proteins / metabolism genetics Melanoma, Experimental / therapy pathology Tumor Suppressor Protein p53 / metabolism genetics PTEN Phosphohydrolase / metabolism genetics
来 源:
DOI:10.3390/v16071153
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