Rupestonic 酸衍生物 YZH - 106 通过与 PreS2 结构域的直接相互作用促进 HBV L - 和 M - HBsAg 的溶酶体降解。
关键词: HBV HBsAg YZH-106 degradation
Mesh : Humans Hepatitis B virus / drug effects genetics Hepatitis B Surface Antigens / metabolism Lysosomes / metabolism Virus Replication / drug effects Hepatitis B / virology drug therapy Antiviral Agents / pharmacology Proteolysis Hep G2 Cells Hepatocytes / virology metabolism Molecular Docking Simulation Protein Binding Protein Precursors
来 源:
DOI:10.3390/v16071151
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