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Abstract：
Sheeppox virus (SPPV), goatpox virus (GTPV), and lumpy skin disease virus (LSDV) are the three members of the genus Capripoxvirus within the Poxviridae family and are the etiologic agents of sheeppox (SPP), goatpox (GTP), and lumpy skin disease (LSD), respectively. LSD, GTP, and SPP are endemic in Africa and Asia, causing severe disease outbreaks with significant economic losses in livestock. Incursions of SPP and LSD have occurred in Europe. Vaccination with live attenuated homologous and heterologous viruses are routinely implemented to control these diseases. Using the gold standard virus neutralization test, we studied the ability of homologous and heterologous sera to neutralize the SPPV and LSDV. We found that LSD and SPP sera effectively neutralize their homologous viruses, and GTP sera can neutralize SPPV. However, while LSD sera effectively neutralizes SPPV, SPP and GTP sera cannot neutralize the LSDV to the same extent. We discuss the implications of these observations in disease assay methodology and heterologous vaccine efficacy.
摘要：
羊痘病毒(SPPV)山羊痘病毒（GTPV），和块状皮肤病病毒（LSDV）是Poxviridae家族中的Capropoxvirus属的三个成员，是羊痘（SPP）的病原体，山痘（GTP），和块状皮肤病（LSD），分别。LSD,GTP,SPP在非洲和亚洲流行，在牲畜中造成严重的疾病爆发和重大的经济损失。在欧洲发生了SPP和LSD的入侵。常规实施用活的减毒同源和异源病毒的疫苗接种以控制这些疾病。使用金标准病毒中和试验，我们研究了同源和异源血清中和SPPV和LSDV的能力。我们发现LSD和SPP血清能有效地中和它们的同源病毒,GTP血清可中和SPPV。然而,而LSD血清有效中和SPPV，SPP和GTP血清不能以相同的程度中和LSDV。我们讨论了这些观察结果在疾病检测方法和异源疫苗功效中的意义。
