PDF(Pubmed)
Abstract：
Viruses often pose a significant threat to the host through the exploitation of cellular machineries for their own benefit. In the context of immune responses, myriad host factors are deployed to target viral RNAs and inhibit viral protein translation, ultimately hampering viral replication. Understanding how \"non-self\" RNAs interact with the host translation machinery and trigger immune responses would help in the development of treatment strategies for viral infections. In this review, we explore how interferon-stimulated gene products interact with viral RNA and the translation machinery in order to induce either global or targeted translation inhibition.
摘要：
为了自身的利益,病毒通常通过利用细胞机器对宿主构成重大威胁。在免疫反应的背景下，无数的宿主因子被部署到靶向病毒RNA和抑制病毒蛋白翻译，最终阻碍病毒复制。了解“非自身”RNA如何与宿主翻译机制相互作用并触发免疫反应将有助于开发病毒感染的治疗策略。在这次审查中,我们探索干扰素刺激的基因产物如何与病毒RNA和翻译机制相互作用，以诱导全局或靶向翻译抑制。
