PDF(Pubmed)
Abstract：
The BET (bromodomain and extraterminal domain) family of proteins, particularly BRD4 (bromodomain-containing protein 4), plays a crucial role in transcription regulation and epigenetic mechanisms, impacting key cellular processes such as proliferation, differentiation, and the DNA damage response. BRD4, the most studied member of this family, binds to acetylated lysines on both histones and non-histone proteins, thereby regulating gene expression and influencing diverse cellular functions such as the cell cycle, tumorigenesis, and immune responses to viral infections. Given BRD4\'s involvement in these fundamental processes, it is implicated in various diseases, including cancer and inflammation, making it a promising target for therapeutic development. This review comprehensively explores the roles of the BET family in gene transcription, DNA damage response, and viral infection, discussing the potential of targeted small-molecule compounds and highlighting BET proteins as promising candidates for anticancer therapy.
摘要：
蛋白质的BET（溴结构域和外结构域）家族，特别是BRD4（含溴结构域蛋白4），在转录调控和表观遗传机制中起着至关重要的作用，影响关键的细胞过程，如增殖，分化,和DNA损伤反应。BRD4这个家族研究最多的成员,与组蛋白和非组蛋白蛋白上的乙酰化赖氨酸结合，从而调节基因表达和影响不同的细胞功能，如细胞周期，肿瘤发生，和对病毒感染的免疫反应。鉴于BRD4参与了这些基本过程，它与各种疾病有关，包括癌症和炎症，使其成为治疗发展的有希望的目标。本文综述了BET家族在基因转录中的作用,DNA损伤反应,和病毒感染，讨论靶向小分子化合物的潜力，并强调BET蛋白作为抗癌治疗的有希望的候选者。
