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Abstract：
This work explores the transformative role of graphene in enhancing the performance of surface plasmon resonance (SPR)-based biosensors. The motivation for this review stems from the growing interest in the unique properties of graphene, such as high surface area, excellent electrical conductivity, and versatile functionalization capabilities, which offer significant potential to improve the sensitivity, specificity, and stability of SPR biosensors. This review systematically analyzes studies published between 2010 and 2023, covering key metrics of biosensor performance. The findings reveal that the integration of graphene consistently enhances sensitivity. Specificity, although less frequently reported numerically, showed promising results, with high specificity achieved at sub-nanomolar concentrations. Stability enhancements are also significant, attributed to the protective properties of graphene and improved biomolecule adsorption. Future research should focus on mechanistic insights, optimization of integration techniques, practical application testing, scalable fabrication methods, and comprehensive comparative studies. Our findings provide a foundation for future research, aiming to further optimize and harness the unique physical properties of graphene to meet the demands of sensitive, specific, stable, and rapid biosensing in various practical applications.
摘要：
这项工作探讨了石墨烯在增强基于表面等离子体共振（SPR）的生物传感器性能方面的转化作用。这篇综述的动机源于人们对石墨烯独特特性的兴趣与日俱增，如高表面积，优异的导电性，和多功能的功能化能力，这提供了巨大的潜力来提高灵敏度，特异性，SPR生物传感器的稳定性。这篇综述系统分析了2010年至2023年之间发表的研究，涵盖了生物传感器性能的关键指标。研究结果表明，石墨烯的整合始终增强了灵敏度。特异性,虽然数字报道较少，显示出有希望的结果，具有在亚纳摩尔浓度下实现的高特异性。稳定性增强也很显著,归因于石墨烯的保护性能和改进的生物分子吸附。未来的研究应该集中在机械论的洞察力上，集成技术的优化，实际应用测试，可扩展的制造方法，综合比较研究。我们的发现为未来的研究奠定了基础，旨在进一步优化和利用石墨烯独特的物理性质，以满足敏感的需求，具体,稳定,和各种实际应用中的快速生物传感。
