Abstract:
Diabetes is a widespread chronic disease that occurs mainly in the elderly population. Due to the difference in pathophysiology between elderly and young patients, the current clinical practice to treat elderly patients with anti-diabetes medications still faces some challenges and dilemmas, such as the urgent need for early diagnosis and prevention, and an imbalance between restricted dietary intake and the risk of undernutrition. Traditional Chinese medicine (TCM) offers various treatment regimens that are actively utilized in the field of diabetes management. Through multiple targets and multiple pathways, TCM formulas, medicinal herbs, and active natural products enhance the efficacy of diabetes prevention and diabetes control measures, simplify complex medication management, and improve common symptoms and common diabetic complications in elderly people. Historically, natural products have played a key role in material composition analysis of TCM and mechanism interpretation to enable drug discovery. However, there have been few conclusions on this topic. This review summarizes the development of TCM for the prevention and management of diabetes in elderly people, existing evidence-based clinical practices, and prospects for future development.
摘要:
糖尿病是一种广泛存在的慢性疾病,主要发生在老年人群。由于老年和年轻患者在病理生理学上的差异,目前临床实践中治疗老年患者抗糖尿病药物仍面临一些挑战和困境,例如迫切需要早期诊断和预防,以及限制饮食摄入和营养不良风险之间的不平衡。传统中药(TCM)提供了在糖尿病管理领域积极利用的各种治疗方案。通过多个靶标和多个途径,中药配方,草药,和活性天然产物增强糖尿病预防和糖尿病控制措施的功效,简化复杂的药物管理,改善老年人常见症状和常见糖尿病并发症。历史上,天然产物在中药的物质成分分析和机制解释以发现药物方面发挥了关键作用。然而,关于这个话题几乎没有结论。本文综述了中医防治老年糖尿病的研究进展,现有的循证临床实践,和未来发展前景。