PDF(Pubmed)
Abstract：
Androgenetic alopecia (AGA) is a highly prevalent condition in contemporary society. The conventional treatment of minoxidil tincture is hindered by issues such as skin irritation caused by ethanol, non-specific accumulation in hair follicles, and short retention due to its liquid form. Herein, we have developed a novel minoxidil-incorporated engineered exosomes biopotentiated hydrogel (Gel@MNs) that has the capability to modulate the perifollicular microenvironment for the treatment of AGA. Leveraging the exceptional skin penetration abilities of flexible liposomes and the targeting properties of exosomes, the encapsulated minoxidil can be effectively delivered to the hair follicles. In comparison to free minoxidil, Gel@MNs demonstrated accelerated hair regeneration in an AGA mouse model without causing significant skin irritation. This was evidenced by an increase in both the number and size of hair follicles within the dermal layer, enhanced capillary formation surrounding the follicles, and the regulation of the transition of hair follicle cells from the telogen phase to the anagen growth phase. Therefore, this safe and microenvironment-modifying hybrid exosome-embedded hydrogel shows promising potential for clinical treatment of AGA.
摘要：
雄激素性脱发（AGA）是当代社会中非常普遍的疾病。米诺地尔tin剂的常规治疗受到乙醇引起的皮肤刺激等问题的阻碍，在毛囊中的非特异性积累，和短保留由于其液体形式。在这里，我们开发了一种新型的结合米诺地尔的工程化外泌体生物强化水凝胶(Gel@MNs),该凝胶具有调节卵泡周围微环境的能力,用于治疗AGA.利用柔性脂质体的特殊皮肤渗透能力和外泌体的靶向特性，封装的米诺地尔可以有效地递送到毛囊。与游离米诺地尔相比,凝胶@MNs在AGA小鼠模型中表现出加速的毛发再生而不引起显著的皮肤刺激。真皮层内毛囊的数量和大小的增加证明了这一点，毛囊周围的毛细血管形成增强，以及毛囊细胞从静止期到生长期的过渡调节。因此,这种安全和微环境修饰的混合外泌体嵌入水凝胶显示了临床治疗AGA的有希望的潜力。
