PDF(Pubmed)
Abstract：
Microneedles are an innovation in the field of medicine that have the potential to revolutionize drug delivery, diagnostics, and cosmetic treatments. This innovation provides a minimally invasive means to deliver drugs, vaccines, and other therapeutic substances into the skin. This research investigates the design and manufacture of customized microneedle arrays using laser ablation. Laser ablation was performed using an ytterbium laser on a polymethyl methacrylate (PMMA) substrate to create a mold for casting polydimethylsiloxane (PDMS) microneedles. An experimental design was conducted to evaluate the effect of process parameters including laser pulse power, pulse width, pulse repetition, interval between pulses, and laser profile on the desired geometry of the microneedles. The analysis of variance (ANOVA) model showed that lasing interval, laser power, and pulse width had the highest influence on the output metrics (diameter and height) of the microneedle. The microneedle dimensions showed an increase with higher pulse width and vice versa with an increase in pulse interval. A response surface model indicated that the laser pulse width and interval (independent variables) significantly affect the response diameter and height (dependent variable). A predictive model was generated to predict the microneedle topology and aspect ratio varying from 0.8 to 1.5 based on the variation in critical input process parameters. This research lays the foundation for the design and fabrication of customized microneedles based on variations in specific input parameters for therapeutic applications in dermal sensors, drug delivery, and vaccine delivery.
摘要：
微针是医学领域的一项创新，有可能彻底改变药物输送，诊断,和美容治疗。这项创新提供了一种微创手段来输送药物，疫苗,和其他治疗物质进入皮肤。这项研究调查了使用激光烧蚀的定制微针阵列的设计和制造。使用镱激光器在聚甲基丙烯酸甲酯(PMMA)基底上进行激光烧蚀以产生用于铸造聚二甲基硅氧烷(PDMS)微针的模具。进行了实验设计，以评估包括激光脉冲功率在内的工艺参数的影响，脉冲宽度,脉冲重复,脉冲之间的间隔，和在微针的所需几何形状上的激光轮廓。方差分析(ANOVA)模型显示,激光功率,和脉冲宽度对微针的输出度量（直径和高度）的影响最大。微针尺寸随着脉冲宽度的增加而增加,反之亦然随着脉冲间隔的增加。响应面模型表明，激光脉冲宽度和间隔（自变量）显着影响响应直径和高度（因变量）。生成预测模型以基于关键输入过程参数的变化来预测微针拓扑结构和纵横比从0.8变化到1.5。这项研究为定制微针的设计和制造奠定了基础，这些微针基于皮肤传感器中治疗应用的特定输入参数的变化，药物输送,和疫苗交付。
