PDF(Pubmed)
Abstract：
Nanocellulose (NC) is a promising material for drug delivery due to its high surface area-to-volume ratio, biocompatibility, biodegradability, and versatility in various formats (nanoparticles, hydrogels, microspheres, membranes, and films). In this study, nanocellulose films were derived from \"Bolaina blanca\" (Guazuma crinita) and combined with nanoporous silicon microparticles (nPSi) in concentrations ranging from 0.1% to 1.0% (w/v), using polyvinyl alcohol (PVA) as a binding agent to create NC/nPSi composite films for drug delivery systems. The physicochemical properties of the samples were characterized using UV-Vis spectroscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The mechanical properties and drug release capabilities were also evaluated using methylene blue (MB) as an antibacterial drug model. Antibacterial assays were conducted against S. aureus and E. coli bacteria. The results show that NC/nPSi composites with 1% nPSi increased the T50% by 10 °C and enhanced mechanical properties, such as a 70% increase in the elastic modulus and a 372% increase in elongation, compared to NC films. Additionally, MB released from NC/nPSi composites effectively inhibited the growth of both bacteria. It was also observed that the diffusion coefficients were inversely proportional to the % nPSi. These findings suggest that this novel NC/nPSi-based material can serve as an effective controlled drug release system.
摘要：
纳米纤维素（NC）由于其高表面积与体积比，是一种有前途的药物输送材料，生物相容性，生物降解性，和各种格式的多功能性(纳米粒子，水凝胶,微球,膜，和电影）。在这项研究中,纳米纤维素膜来自“Bolainablanca”（Guazumacrinita），并与浓度范围为0.1％至1.0％（w/v）的纳米多孔硅微粒（nPSi）结合，使用聚乙烯醇（PVA）作为粘合剂，以创建用于药物递送系统的NC/nPSi复合膜。利用紫外-可见光谱对样品的理化性质进行了表征,扫描电子显微镜（SEM），傅里叶变换红外光谱衰减全反射(FTIR-ATR),X射线衍射(XRD)和热重分析(TGA)。还使用亚甲基蓝（MB）作为抗菌药物模型评估了机械性能和药物释放能力。针对金黄色葡萄球菌和大肠杆菌细菌进行抗菌试验。结果表明，具有1％nPSi的NC/nPSi复合材料将T50％提高了10°C，并增强了机械性能，如弹性模量增加70%，伸长率增加372%，与NC胶片相比。此外,从NC/nPSi复合材料中释放的MB有效地抑制了两种细菌的生长。还观察到扩散系数与%nPSi成反比。这些发现表明，这种新型的基于NC/nPSi的材料可以用作有效的受控药物释放系统。
