RESULTS: During the period of investigation (January 2017-December 2022), 78 patients diagnosed with infective endocarditis (IE) on a prosthetic valve were admitted to the Infectious Diseases Department of the \"Dr. Carol Davila\" Central Military Emergency University Hospital in Bucharest. In 28 patients (35.8%), the onset of PVE occurred within 12 months of surgery (early onset), whereas in 50 patients (64.2%), the onset occurred more than 12 months after surgery (late onset). The mortality rate was 35.9% (53.6% among the early onset patients and 26% among the late-onset patients). Among patients who received surgical and medical therapy, the mortality rate was 29.6%, whereas among those who received only medical therapy, a 39.2% mortality rate was reported. According to the extracted data, antibiotic therapy was successful in 72.6% of the patients. In contrast, a combination of surgical and drug-based approaches resulted in a cure in 76.1% of patients. The most common etiological agent was Staphylococcus aureus (38.5%), followed by Enterococcus faecalis (26.9%) and Streptococcus mitis (10.3%). The mortality rate of patients infected with S. aureus was 29.2%, indicating the severity of this infectious agent.
CONCLUSIONS: Prosthetic valve endocarditis (PVE) is a serious condition associated with a high mortality rate both in the short and long term. Regardless of the therapy used, the risk of death remains high.
结果:在调查期间(2017年1月至2022年12月),78例被诊断为人工瓣膜感染性心内膜炎(IE)的患者被送往布加勒斯特中央军事急诊大学医院的感染科。在28例患者(35.8%)中,PVE的发作发生在手术后12个月内(早期发作),而在50例患者(64.2%)中,发病发生在手术后12个月以上(晚发病).死亡率为35.9%(早发型患者为53.6%,晚发型患者为26%)。在接受手术和药物治疗的患者中,死亡率为29.6%,而在那些只接受药物治疗的人中,报告了39.2%的死亡率.根据提取的数据,72.6%的患者使用抗生素治疗成功.相比之下,手术和基于药物的方法的组合导致76.1%的患者治愈.最常见的病原体是金黄色葡萄球菌(38.5%),其次是粪肠球菌(26.9%)和链球菌(10.3%)。金黄色葡萄球菌感染患者的死亡率为29.2%,表明这种传染因子的严重程度。
结论:人工瓣膜心内膜炎(PVE)是一种与短期和长期高死亡率相关的严重疾病。不管用什么疗法,死亡的风险仍然很高。