PDF(Pubmed)
Abstract：
Aging is a complex process and a significant risk factor for chronic diseases. Menopause, a component of aging in women, is associated with several important cardiometabolic conditions including metabolic syndrome, osteoporosis, and cardiovascular diseases. Menopausal women could benefit from preventative strategies that may decrease morbidity and mortality and improve their quality of life. Vitamins D and K are essential nutrients required for bone health, immune function, and reducing cardiovascular risks, yet their synergistic effect is less understood in aging women. This is the first comprehensive review to summarize the evidence found in randomized clinical trials of the beneficial effects of vitamin D and K co-treatment in postmenopausal women. In our literature search across key electronic databases such as Cochrane, PubMed, and Ovid, we identified 31 pertinent studies. Overall, significant findings indicate that the combined intake of vitamins D and K may positively affect cardiovascular and bone health in postmenopausal women, emphasizing the importance of maintaining a healthy diet rich in vegetables and fermented dairy products. Given the challenges in obtaining all necessary nutrients solely through the diet, vitamin D and K supplements are recommended for postmenopausal women to promote healthy aging and well-being.
摘要：
衰老是一个复杂的过程，是慢性疾病的重要风险因素。更年期,女性衰老的一个组成部分，与几种重要的心脏代谢疾病有关，包括代谢综合征，骨质疏松,和心血管疾病。更年期妇女可以从预防策略中受益，这些策略可以降低发病率和死亡率并改善其生活质量。维生素D和K是骨骼健康所需的必需营养素，免疫功能，降低心血管风险，然而，它们的协同作用在老年女性中却鲜为人知。这是第一个全面的综述，总结了在随机临床试验中发现的维生素D和K共同治疗对绝经后妇女有益作用的证据。在我们对关键电子数据库如Cochrane的文献检索中，PubMed,而奥维德,我们确定了31项相关研究.总的来说,重要的发现表明，维生素D和K的联合摄入可能对绝经后妇女的心血管和骨骼健康产生积极影响。强调保持富含蔬菜和发酵乳制品的健康饮食的重要性。鉴于仅通过饮食获得所有必需营养素的挑战，建议绝经后妇女补充维生素D和K，以促进健康衰老和福祉。
