PDF(Pubmed)
Abstract：
Energy drink (ED) consumption among Israeli-Arab adolescents is widespread. This study aimed to investigate the acute glycemic and insulin effects of EDs in healthy adolescents. Seventy-one Israeli-Arab adolescents (56% girls, average age 16.04 ± 1.03 years) participated in a non-randomized, case-controlled, open-label study. Participants consumed ED (n = 36) or a volume- and carbohydrate-matched non-caffeinated soft drink (SD, n = 35), followed by a 2 h glucose tolerance test. Blood glucose was measured at baseline and 15, 30, 60, and 120 min post-consumption (T0, T15, T30, T60 and T120, respectively). Serum insulin concentration and caffeine relative intensity were determined 45 min post-consumption (T45). Blood glucose levels peaked significantly at T15 and remained significantly higher at T30 in the ED group compared to the SD group (p = 0.005, p = 0.017, respectively). Insulin concentrations were substantially higher at T45 in the ED group (t [64] = 2.794, p = 0.001). This pattern was especially prominent in heavy ED consumers. A positive correlation emerged between the amount of caffeine consumed (mg/kg), blood glucose levels at T15 and T30, and insulin concentration at T45. This study is the first to demonstrate the glycemic and insulin responses to ED consumption in adolescents, suggesting that regulatory measures limiting ED sales to adolescents could improve their health.
摘要：
以色列-阿拉伯青少年的能量饮料（ED）消费很普遍。本研究旨在探讨ED对健康青少年急性血糖和胰岛素的影响。71名以色列-阿拉伯青少年(56%为女孩，平均年龄16.04±1.03岁)参加了一项非随机研究，病例控制,开放标签研究。参与者食用ED（n=36）或体积和碳水化合物匹配的不含咖啡因的软饮料（SD，n=35),然后进行2小时葡萄糖耐量试验。在基线和消耗后15、30、60和120分钟测量血糖(分别为T0、T15、T30、T60和T120)。食用后45分钟（T45）确定血清胰岛素浓度和咖啡因相对强度。与SD组相比,ED组的血糖水平在T15显著达到峰值,在T30时保持显著较高(分别为p=0.005,p=0.017)。ED组的胰岛素浓度在T45时显著较高(t[64]=2.794,p=0.001)。这种模式在重度ED消费者中尤为突出。咖啡因的消耗量（mg/kg）之间呈正相关，T15和T30时的血糖水平以及T45时的胰岛素浓度。这项研究首次证明了青少年对ED消耗的血糖和胰岛素反应，这表明，限制向青少年销售ED的监管措施可以改善他们的健康状况。
