PDF(Pubmed)
Abstract：
Restless legs syndrome (RLS) is a common neurological disorder. It disrupts sleep and well-being and is often associated with other conditions. This review examines the potential of dietary supplements to manage RLS symptoms and reduce reliance on medications. A total of 10 randomized clinical trials involving 482 participants were analyzed, focusing on the impact of various supplements on symptom severity, sleep quality, and daytime sleepiness. Findings suggest some supplements may have positive results. Magnesium oxide and vitamin B6 significantly improved sleep quality and RLS symptoms, with magnesium showing greater effectiveness. Vitamin D supplementation did not show significant benefits. Oral iron has promising results, indicating potential efficacy but issues related to compliance and absorption. Both vitamins C and E positively affect RLS symptoms, likely due to their antioxidant properties. Valerian improved RLS and sleep but did not show a statistically significant improvement. Despite these encouraging results, a high risk of bias was noted in half of the studies, emphasizing the need for more rigorous research. Overall, this review suggests that dietary supplements may be a promising approach to managing RLS. However, further investigation is required to confirm the efficacy and safety.
摘要：
不宁腿综合征（RLS）是一种常见的神经系统疾病。它会破坏睡眠和健康，并经常与其他条件有关。这篇综述探讨了膳食补充剂管理RLS症状和减少对药物依赖的潜力。共分析了10项随机临床试验，涉及482名参与者，关注各种补充剂对症状严重程度的影响，睡眠质量,和白天嗜睡。研究结果表明，一些补充剂可能有积极的结果。氧化镁和维生素B6显著改善睡眠质量和RLS症状，镁表现出更大的效力。补充维生素D并没有显示出显著的益处。口服铁具有良好的效果，表明潜在的疗效，但与依从性和吸收有关的问题。维生素C和E都对RLS症状有积极影响，可能是由于它们的抗氧化性能。缬草改善了RLS和睡眠，但没有显示出统计学上的显着改善。尽管有这些令人鼓舞的结果，在一半的研究中发现了高偏倚风险，强调需要更严格的研究。总的来说,这篇综述表明,膳食补充剂可能是管理RLS的一种有希望的方法.然而,需要进一步调查以确认疗效和安全性。
