PDF(Pubmed)
Abstract：
The compounds known as flavonoids, commonly found in fruits, vegetables, legumes, medicinal herbs, chocolate, and coffee and tea beverages, have been extensively researched for their impact on cardiovascular health. Flavonoids, with their demonstrated potential, have shown promising effects in regulating blood vessel function and apoptotic processes, as well as in improving lipid profiles. While their powerful antioxidant properties were initially thought to be the main reason behind these effects, recent studies have uncovered new insights into the positive effects of flavonoids on cardiovascular health, and researchers have now identified several signaling pathways and mechanisms that also play a role. Of particular interest are the studies that have highlighted the role of autophagy in maintaining the physiological functions of cardiomyocytes and protecting them from harm. Recent publications have linked the dysregulation of autophagic processes with the development of cardiomyopathies, heart failure, and other cardiovascular diseases. This review aims to present the latest, novel findings from preclinical research regarding the potential beneficial effects of flavonoids on various heart conditions associated with altered autophagy processes.
摘要：
被称为类黄酮的化合物，常见于水果中，蔬菜,豆类,草药,巧克力,咖啡和茶饮料，对它们对心血管健康的影响进行了广泛的研究。黄酮类化合物,凭借他们展示的潜力，在调节血管功能和凋亡过程方面显示出有希望的效果，以及改善血脂状况。虽然它们强大的抗氧化特性最初被认为是这些影响背后的主要原因，最近的研究发现了黄酮类化合物对心血管健康的积极影响的新见解，研究人员现在已经确定了几种信号通路和机制也起作用。特别令人感兴趣的是强调自噬在维持心肌细胞的生理功能和保护它们免受伤害中的作用的研究。最近的出版物将自噬过程的失调与心肌病的发展联系起来，心力衰竭,和其他心血管疾病。这篇评论旨在介绍最新的情况，关于黄酮类化合物对与自噬过程改变相关的各种心脏病的潜在有益作用的临床前研究的新发现。
