PDF(Pubmed)
Abstract：
Background and Objectives: Renal cell carcinomas and upper tract urothelial carcinomas are types of malignancies that originate in the kidneys. Each of these examples shows an increasing trend in the frequency and the mortality rate. This study aims to comprehensively define carcinomas by analyzing clinical, paraclinical, and histological aspects to predict aggressiveness and mortality. Materials and Methods: We conducted a retrospective investigation on a group of patients suspected of kidney cancers. Results: We identified 188 cases. We observed a higher mortality rate and older age in individuals with urothelial carcinomas. Anemia, acute kidney injury, hematuria, and perineural invasion were the main risk factors that predicted their mortality. Tumor size in renal cell carcinomas correlates with the presence of necrosis and sarcomatoid areas. Factors that indicate a higher rate of death are older age, exceeding the renal capsule, a lesion that includes the entire kidney, lymphovascular invasion, acute kidney injury, and anemia. Conclusions: Even if they originate at the renal level, and the clinical-paraclinical picture is similar, the histopathological characteristics make the difference. In addition, to these are added the previously mentioned common parameters that can represent important prognostic factors. In conclusion, the characteristics commonly identified in one type of cancer may act as risk factors for the other tumor. The detected data include threshold values and risk factors, making a significant contribution to the existing literature.
摘要：
背景和目的：肾细胞癌和上尿路上皮癌是起源于肾脏的恶性肿瘤。这些例子中的每一个都显示出频率和死亡率的增加趋势。本研究旨在通过临床分析全面定义癌症，临床旁,和组织学方面来预测侵袭性和死亡率。材料和方法：我们对一组怀疑患有肾癌的患者进行了回顾性调查。结果：我们确定了188例。我们观察到尿路上皮癌患者的死亡率更高，年龄更大。贫血,急性肾损伤，血尿,和神经周浸润是预测其死亡率的主要危险因素。肾细胞癌的肿瘤大小与坏死和肉瘤样区的存在相关。表明死亡率较高的因素是年龄较大，超过肾包膜，包括整个肾脏的病变，淋巴管浸润,急性肾损伤，和贫血。结论：即使它们起源于肾脏水平，临床-副临床图像相似，组织病理学特征造成了差异。此外,在这些参数中增加了前面提到的可以代表重要预后因素的共同参数.总之,在一种类型的癌症中常见的特征可能是另一种肿瘤的危险因素。检测到的数据包括阈值和风险因素，对现有文献做出了重大贡献。
