PDF(Pubmed)
Abstract：
Background and Objectives: Several studies suggest the complex relationship between Endothelin-1 (ET-1) levels with various types of glaucoma. This systematic review and meta-analysis explore ET-1 levels in plasma and aqueous humor among different types of glaucoma. Materials and Methods: A literature search (PubMed, ScienceDirect, Cochrane Library) was made up to April 2024 (PROSPERO: CRD42023430471). The results were synthesized according to PRISMA Guidelines. Results were presented as standardized mean differences (SMD) with 95% confidence intervals (CI). Results: A total of 2597 subjects (1513 patients with glaucoma vs. 1084 healthy controls) from 23 studies were included in a meta-analysis. Notably, patients with glaucoma reported significantly higher plasma levels of ET-1 compared to controls (SMD: 1.21, 95% CI: 0.59-1.82, p < 0.001). Particularly, plasma ET-1 levels were higher in primary open-angle glaucoma (POAG) (SMD: 0.87, 95% CI: 0.09-1.65, p < 0.05), normal-tension glaucoma (SMD: 0.86, 95% CI: 0.27-1.46, p = 0.05), and angle-closure glaucoma patients (SMD: 1.03, 95% CI: 0.43-1.63, p < 0.001) compared to healthy controls. Moreover, ET-1 aqueous humor levels were significantly higher in patients with glaucoma compared to controls (SMD: 1.60, 95% CI: 1.04-2.15, p < 0.001). In particular, aqueous humor levels were higher in POAG patients (SMD: 2.03 95% CI: 1.00-3.14, p < 0.001), and pseudoexfoliative glaucoma patients (SMD: 2.03, 95% CI: 1.00-3.07, p < 0.001) compared to controls. Conclusions: This meta-analysis indicates that elevated levels of ET-1 plasma and aqueous humor are significantly associated with different types of glaucoma. The pathogenesis of ET-1-related mechanisms may vary across different glaucoma types, indicating that possible therapeutic approaches targeting ET-1 pathways should be tailored to each specific glaucoma type.
摘要：
背景和目的：多项研究表明内皮素-1（ET-1）水平与各种类型的青光眼之间存在复杂的关系。本系统评价和荟萃分析探讨了不同类型青光眼患者血浆和房水中ET-1的水平。材料与方法：文献检索(PubMed，ScienceDirect,Cochrane图书馆）制作至2024年4月（PROSPERO：CRD42023430471）。根据PRISMA指南合成结果。结果表示为具有95%置信区间(CI)的标准化平均差(SMD)。结果：共有2597名受试者（1513名青光眼患者与来自23项研究的1084名健康对照）被纳入荟萃分析。值得注意的是,青光眼患者的血浆ET-1水平明显高于对照组(SMD:1.21,95%CI:0.59-1.82,p<0.001).特别是,原发性开角型青光眼（POAG）血浆ET-1水平较高（SMD：0.87，95％CI：0.09-1.65，p<0.05），正常眼压性青光眼(SMD:0.86,95%CI:0.27-1.46,p=0.05),与健康对照组相比，闭角型青光眼患者（SMD：1.03，95％CI：0.43-1.63，p<0.001）。此外，与对照组相比，青光眼患者的ET-1房水水平显着升高（SMD：1.60，95％CI：1.04-2.15，p<0.001）。特别是,POAG患者的房水水平较高（SMD：2.0395％CI：1.00-3.14，p<0.001），与对照组相比，假性剥脱性青光眼患者（SMD：2.03，95％CI：1.00-3.07，p<0.001）。结论：这项荟萃分析表明，血浆ET-1和房水水平升高与不同类型的青光眼显着相关。ET-1相关机制的发病机制可能因不同类型的青光眼而异。这表明针对ET-1途径的可能治疗方法应针对每种特定类型的青光眼进行调整。
