PDF(Pubmed)
Abstract：
Background and Objectives: The literature suggests that physiological menopause (MP) seems linked with increased adiposity with a preference for intra-abdominal fat accumulation, greater than what can be attributed only by aging, which could magnify this period\'s increased cardiovascular risk. Materials and Methods: We retrospectively analyzed two age and body mass index (BMI) propensity-matched subgroups each formed of 90 clinically healthy, 40-60-year-old postmenopausal women, within the first 5 and 5-10 years of MP. The 10-year ASCVD risk was assessed using medical history, anthropometric data, and lipid profile blood tests. The android-to-gynoid (A/G) ratio was computed using Lunar osteodensitometry lumbar spine and hip scans. Results: The A/G ratio was significantly higher for the subgroup evaluated in years 5-10 of MP than in the first 5 years of MP, even after controlling for BMI (1.05 vs. 0.99, p = 0.005). While displaying a significant negative correlation with HDL cholesterol (r = 0.406), the A/G ratio also had positive correlations with systolic blood pressure (BP) values (r = 0.273), triglycerides (r = 0.367), and 10-year ASCVD risk (r = 0.277). After adjusting for smoking, hypertension treatment, and type 2 diabetes, the 10-year ASCVD risk became significantly different for women in the first 5 years (3.28%) compared to those in years 5-10 of MP (3.74%), p = 0.047. Conclusions: In women with similar age and BMI, the A/G ratio appears to vary based on the number of years since menopause onset and correlates with either independent cardiovascular risk parameters like BP, triglycerides, and HDL cholesterol or with composite scores, such as 10-year ASCVD risk.
摘要：
背景和目的：文献表明，生理绝经（MP）似乎与肥胖增加有关，偏爱腹内脂肪堆积，大于只能归因于衰老的，这可能会放大这一时期增加的心血管风险。材料和方法：我们回顾性分析了两个年龄和体重指数（BMI）倾向匹配的亚组，每个亚组由90名临床健康，40-60岁的绝经后妇女，在MP的前5和5-10年内。使用病史评估10年ASCVD风险，人体测量数据,血脂和血液检查.使用月球骨密度仪腰椎和髋部扫描计算android-gynoid（A/G）比率。结果：在MP的第5-10年评估的亚组的A/G比率明显高于MP的前5年，即使在控制BMI之后（1.05vs.0.99，p=0.005）。与HDL胆固醇呈显著负相关(r=0.406),A/G比值也与收缩压（BP）值呈正相关（r=0.273），甘油三酯（r=0.367），和10年ASCVD风险（r=0.277）。调整吸烟后，高血压治疗,和2型糖尿病，与MP的5-10年（3.74％）相比，女性在前5年（3.28％）的10年ASCVD风险显着不同，p=0.047。结论：在年龄和BMI相似的女性中，A/G比似乎根据绝经后的年数而变化，并且与独立的心血管风险参数如BP相关，甘油三酯，和高密度脂蛋白胆固醇或综合评分，如10年ASCVD风险。
