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Abstract：
Background and Objectives: An oral lichen planus (OLP) chronic lesion refers to a group of oral potentially malignant disorders (OPMDs) that still lack a proper understanding from the point of view of relevant biomarkers for diagnostics and prognosis. The aim of the study was to assess the salivary histamine levels in patients with oral lichen planus lesions. Materials and Methods: The study included a group of 76 patients with oral lichen planus. General diseases and medication taken, smoking habits, severity of pain assessed using a visual analogue scale (VAS), oral hygiene status, and duration of OLP were evaluated. ELISA diagnostics for histamines in saliva levels were assessed. Results: The histamine levels in the OLP group were higher (0.468) in comparison with the control group (0.056), without a statistically significant value p = 0.090 (Mann-Whitney U Test). The median age of 76 OLP patients was 63 years (min 22.0-max. 81), with the biological sex being 80.3% females and 15 19.7% males. The average duration of OLP lesion presence was 29.4 months (SD 37.1) and the median value was 14.5 months. The median of the VAS was 3.0. OLP assessment in accordance with the Malhotra methodology showed the highest frequency-30.3% for only two of the point areas involved and 17.1% for three points. Clinical assessment of the different OLP grades, severity, and oral site involvement and the VAS in correlation with histamine salivary levels showed a lack of statistical significance in the investigated population. Conclusions: Undertaking further research could provide further possibilities for searching for general factors in OLP development.
摘要：
背景和目的：口腔扁平苔藓（OLP）慢性病变是指一组潜在的口腔恶性疾病（OPMDs），从诊断和预后的相关生物标志物的角度仍然缺乏适当的认识。该研究的目的是评估口腔扁平苔藓病变患者的唾液组胺水平。材料和方法：本研究包括一组76例口腔扁平苔藓患者。一般疾病和药物治疗，吸烟习惯,使用视觉模拟量表（VAS）评估疼痛的严重程度，口腔卫生状况,评估OLP的持续时间。评估唾液中组胺水平的ELISA诊断。结果:OLP组的组胺水平(0.468)高于对照组(0.056),无统计学显著值p=0.090(Mann-WhitneyU检验)。76名OLP患者的中位年龄为63岁（最小22.0-最大。81),生物性别为80.3%的女性和1519.7%的男性。OLP病变存在的平均持续时间为29.4个月（SD37.1），中位数为14.5个月。VAS的中位数为3.0。根据Malhotra方法进行的OLP评估显示，频率最高，仅涉及两个点区域的频率为30.3％，三个点的频率为17.1％。不同OLP等级的临床评估，严重程度,口腔部位受累和与组胺唾液水平相关的VAS在被调查人群中缺乏统计学意义。结论：进行进一步的研究可以为寻找OLP发展的一般因素提供进一步的可能性。
