PDF(Pubmed)
Abstract：
Background: The relationship between serum glycoprotein syndecan-1 and disease activity in rheumatoid arthritis (RA) is still unknown. This study aimed to evaluate whether serum syndecan-1 concentrations are associated with moderate/severe disease activity. Methods: Study Design: This was a cross-sectional study. Seventy-five adult women with RA were classified into (a) moderate/severe RA based on the disease activity score, using the erythrocyte sedimentation rate (DAS28-ESR ≥ 3.2, n = 50), and (b) RA in remission (DAS28-ESR < 2.6, n = 25). Twenty-five healthy women were taken as the reference group. Syndecan-1 levels were determined using enzyme-linked immunosorbent assay (ELISA). High values of serum syndecan-1 levels (≥24 ng/mL) were used to identify the utility values of this biomarker. Results: The patients with RA had higher levels of syndecan-1 than the controls (p < 0.001). RA patients with active disease had higher syndecan-1 levels than RA patients in remission (57.6 vs. 23.5 ng/mL, respectively; p = 0.002). High syndecan-1 concentrations demonstrated the following utility values for identifying disease activity: sensitivity, 84% (95%CI: 71-93); specificity, 52% (95%CI: 31-72); positive predictive value, 78% (95%CI: 70-84); and negative predictive value, 62% (95%CI: 44-77). Conclusions: High syndecan-1 levels have good sensitivity and positive predictive value for identifying disease activity; however, their specificity is limited. Future prospective studies are needed to assess whether syndecan-1 levels can predict treatment failure in RA.
摘要：
背景：血清糖蛋白syndecan-1与类风湿关节炎（RA）疾病活动性之间的关系尚不清楚。本研究旨在评估血清syndecan-1浓度是否与中度/重度疾病活动相关。方法：研究设计：这是一项横断面研究。根据疾病活动性评分，将75名患有RA的成年女性分为（a）中度/重度RA，使用红细胞沉降率(DAS28-ESR≥3.2，n=50)，和(b)RA缓解期(DAS28-ESR<2.6,n=25)。以25名健康女性为参照组。使用酶联免疫吸附测定(ELISA)测定Syndecan-1水平。血清syndecan-1水平的高值（≥24ng/mL）用于鉴定该生物标志物的效用值。结果：RA患者的syndecan-1水平高于对照组（p<0.001）。患有活动性疾病的RA患者的syndecan-1水平高于缓解期的RA患者（57.6vs.23.5ng/mL,分别为；p=0.002)。高syndecan-1浓度证明了以下识别疾病活动的效用值：敏感性，84%（95CI：71-93）；特异性，52%（95CI：31-72）；阳性预测值，78%（95CI：70-84）；阴性预测值，62%（95CI：44-77）。结论：高syndecan-1水平对识别疾病活动具有良好的敏感性和阳性预测价值；然而，它们的特异性是有限的。未来的前瞻性研究需要评估syndecan-1水平是否可以预测RA的治疗失败。
