PDF(Pubmed)
Abstract：
Plasmodium, a digenetic parasite, requires a host and a vector for its life cycle completion. Most Plasmodium species display circadian rhythmicity during their intraerythrocytic cycle within the host, aiding in immune evasion. This rhythmicity, however, diminishes in in vitro cultures, highlighting the importance of host-derived signals for synchronizing the parasite\'s asexual cycle. Studies indicate a species-specific internal clock in Plasmodium, dependent on these host signals. Melatonin, a hormone the pineal gland produces under circadian regulation, impacts various physiological functions and is extensively reviewed as the primary circadian marker affecting parasite rhythms. Research suggests that melatonin facilitates synchronization through the PLC-IP3 signaling pathway, activating phospholipase C, which triggers intracellular calcium release and gene expression modulation. This evidence strongly supports the role of melatonin as a key circadian marker for parasite synchronization, presenting new possibilities for targeting the melatonin pathway when developing novel therapeutic approaches.
摘要：
疟原虫,一种双遗传寄生虫，需要一个宿主和一个载体来完成其生命周期。大多数疟原虫物种在宿主内的红细胞内周期中表现出昼夜节律，帮助逃避免疫。这种节奏，然而,在体外培养中减少，强调宿主衍生信号对同步寄生虫无性周期的重要性。研究表明疟原虫有一个特定物种的内部时钟,依赖于这些主机信号。褪黑激素,松果体在昼夜节律调节下产生的一种激素，影响各种生理功能，并被广泛评论为影响寄生虫节律的主要昼夜节律标记。研究表明，褪黑激素通过PLC-IP3信号通路促进同步，激活磷脂酶C，触发细胞内钙释放和基因表达调节。该证据强烈支持褪黑激素作为寄生虫同步的关键昼夜节律标志物的作用，在开发新的治疗方法时，为靶向褪黑激素途径提供了新的可能性。
