PDF(Pubmed)
Abstract：
Exposure to heavy metals and lifestyle factors like smoking contribute to the production of free oxygen radicals. This fact, combined with a lowered total antioxidant status, can induce even more damage in the development of ankylosing spondylitis (AS). Despite the fact that some researchers are looking for more genetic factors underlying AS, most studies focus on polymorphisms within the genes encoding the human leukocyte antigen (HLA) system. The biggest challenge is finding the effective treatment of the disease. Genetic factors and the influence of oxidative stress, mineral metabolism disorders, microbiota, and tobacco smoking seem to be of great importance for the development of AS. The data contained in this review constitute valuable information and encourage the initiation and development of research in this area, showing connections between inflammatory disorders leading to the pathogenesis of AS and selected environmental and genetic factors.
摘要：
接触重金属和吸烟等生活方式因素会导致氧自由基的产生。这个事实,结合降低的总抗氧化剂状态，在强直性脊柱炎（AS）的发展过程中会引起更大的损害。尽管一些研究人员正在寻找更多的遗传因素，大多数研究集中在编码人类白细胞抗原（HLA）系统的基因内的多态性。最大的挑战是找到这种疾病的有效治疗方法。遗传因素和氧化应激的影响，矿物质代谢紊乱,微生物群,吸烟似乎对AS的发展非常重要。本审查中包含的数据构成了宝贵的信息，并鼓励该领域研究的启动和发展，显示导致AS发病的炎症性疾病与选定的环境和遗传因素之间的联系。
