PDF(Pubmed)
Abstract：
Neutrophils, traditionally viewed as first responders to infection or tissue damage, exhibit dynamic and diverse roles in ocular health and disease. This review elaborates on previous findings that showed how neutrophils contribute to ocular diseases. In ocular infections, neutrophils play a pivotal role in host defense by orchestrating inflammatory responses to combat pathogens. Furthermore, in optic nerve neuropathies and retinal degenerative diseases like age-related macular degeneration (AMD) and diabetic retinopathy (DR), neutrophils are implicated in neuroinflammation and tissue damage owing to their ability to undergo neutrophil extracellular trap formation (NETosis) and secretion of inflammatory molecules. Targeting neutrophil-dependent processes holds promise as a therapeutic strategy, offering potential avenues for intervention in ocular infections, cancers, and retinal degenerative diseases. Understanding the multifaceted roles of neutrophils in ocular diseases is crucial for developing targeted therapies to improve patient outcomes.
摘要：
中性粒细胞,传统上被视为感染或组织损伤的第一反应者，在眼部健康和疾病中表现出动态和多样化的作用。这篇综述详细阐述了以前的发现，这些发现表明中性粒细胞是如何导致眼部疾病的。在眼部感染中，中性粒细胞通过协调炎症反应来对抗病原体，在宿主防御中起关键作用。此外，在视神经神经病和视网膜退行性疾病，如年龄相关性黄斑变性（AMD）和糖尿病视网膜病变（DR），嗜中性粒细胞参与神经炎症和组织损伤，因为它们能够进行嗜中性粒细胞胞外陷阱形成（NETosis）和分泌炎症分子。靶向中性粒细胞依赖性过程有望成为一种治疗策略，提供干预眼部感染的潜在途径，癌症,和视网膜退行性疾病。了解中性粒细胞在眼部疾病中的多方面作用对于开发靶向治疗以改善患者预后至关重要。
