PDF(Pubmed)
Abstract：
Intrauterine growth restriction leads to an altered lipid and amino acid profile in the cord blood at the end of pregnancy. Pre-pregnancy underweight is an early risk factor for impaired fetal growth. The aim of this study was to investigate whether a pre-pregnancy body mass index (ppBMI) of <18.5 kg/m2, as early as at the beginning of pregnancy, is associated with changes in the umbilical cord metabolome. In a sample of the Survey of Neonates in Pomerania (SNIP) birth cohort, the cord blood metabolome of n = 240 newborns of mothers with a ppBMI of <18.5 kg/m2 with n = 208 controls (ppBMI of 18.5-24.9 kg/m2) was measured by NMR spectrometry. A maternal ppBMI of <18.5 kg/m2 was associated with increased concentrations of HDL4 cholesterol, HDL4 phospholipids, VLDL5 cholesterol, HDL 2, and HDL4 Apo-A1, as well as decreased VLDL triglycerides and HDL2 free cholesterol. A ppBMI of <18.5 kg/m2 combined with poor intrauterine growth (a gestational weight gain (GWG) < 25th percentile) was associated with decreased concentrations of total cholesterol; cholesterol transporting lipoproteins (LDL4, LDL6, LDL free cholesterol, and HDL2 free cholesterol); LDL4 Apo-B; total Apo-A2; and HDL3 Apo-A2. In conclusion, maternal underweight at the beginning of pregnancy already results in metabolic changes in the lipid profile in the cord blood, but the pattern changes when poor GWG is followed by pre-pregnancy underweight.
摘要：
宫内生长受限导致妊娠结束时脐带血中的脂质和氨基酸谱改变。孕前体重不足是胎儿生长受损的早期危险因素。这项研究的目的是调查孕前体重指数（ppBMI）是否<18.5kg/m2，早在怀孕开始时，与脐带代谢组的变化有关。在波美拉尼亚新生儿调查(SNIP)出生队列的样本中，通过NMR光谱法测量了ppBMI<18.5kg/m2的母亲的n=240例新生儿和n=208例对照(ppBMI为18.5-24.9kg/m2)的脐带血代谢组。<18.5kg/m2的母体ppBMI与HDL4胆固醇浓度增加有关。HDL4磷脂，VLDL5胆固醇，HDL2和HDL4Apo-A1，以及降低的VLDL甘油三酯和HDL2游离胆固醇。PPBMI<18.5kg/m2，宫内生长不良（妊娠体重增加（GWG）<25百分位数）与总胆固醇浓度降低有关；胆固醇转运脂蛋白（LDL4，LDL6，LDL游离胆固醇，和HDL2游离胆固醇）；LDL4Apo-B；总Apo-A2；和HDL3Apo-A2。总之,孕妇在怀孕初期体重不足已经导致脐带血中脂质代谢变化，但是当GWG差之后是孕前体重不足时，这种模式会发生变化。
