PDF(Pubmed)
Abstract：
Tibetan sheep are vital to the ecosystem and livelihood of the Tibetan Plateau; however, traditional breeding methods limit their production and growth. Modern molecular breeding techniques are required to improve these traits. This study identified a single nucleotide polymorphism (SNP) in myostatin (MSTN) and Callipyge in Tibetan sheep. The findings indicated notable associations between MSTN genotypes and growth traits including birth weight (BW), body length (BL), chest width (ChW), and chest circumference (ChC), as well as a particularly strong association with cannon circumference (CaC) at 2 months of age. Conversely, Callipyge polymorphisms did not have a significant impact on Tibetan sheep. Moreover, the analyses revealed a significant association between sex and BW or hip width (HW) at 2 months of age and ChW, ChC, and CaC at 4 months of age. Furthermore, the study\'s results suggested that the genotype of MSTN as a GA was associated with a notable sex effect on BW, while the genotype of Callipyge (CC) showed a significant impact of sex on CaC at 2 months of age. These results indicated that the SNP of MSTN could potentially serve as a molecular marker for early growth traits in Tibetan sheep.
摘要：
藏羊对青藏高原的生态系统和生计至关重要；然而，传统的育种方法限制了它们的生产和生长。需要现代分子育种技术来改善这些性状。这项研究在藏羊的肌肉生长抑制素（MSTN）和Callipyge中鉴定了单核苷酸多态性（SNP）。研究结果表明，MSTN基因型与包括出生体重（BW）在内的生长性状之间存在显着关联。体长(BL),胸部宽度（ChW），和胸围（ChC），以及在2个月大时与大炮周长（CaC）的特别强的关联。相反，Callipyge多态性对藏羊没有显著影响。此外，分析显示，性别与2月龄时的BW或髋关节宽度(HW)和CHW之间存在显著关联，ChC,和CaC在4个月大。此外，研究结果表明，作为GA的MSTN基因型与BW的显著性别效应有关，而Callipyge（CC）的基因型在2月龄时显示出性别对CaC的显着影响。这些结果表明，MSTN的SNP可能作为藏绵羊早期生长性状的分子标记。
