PDF(Pubmed)
Abstract：
In mammals, specificity protein 1 (SP1) was the first Cys2-His2 zinc finger transcription factor to be isolated within the specificity protein and Krüppel-like factor (Sp/KLF) gene family. SP1 regulates gene expression by binding to Guanine-Cytosine (GC)-rich sequences on promoter regions of target genes, affecting various cellular processes. Additionally, the activity of SP1 is markedly influenced by posttranslational modifications, such as phosphorylation, acetylation, glycosylation, and proteolysis. SP1 is implicated in the regulation of apoptosis, cell hypertrophy, inflammation, oxidative stress, lipid metabolism, plaque stabilization, endothelial dysfunction, fibrosis, calcification, and other pathological processes. These processes impact the onset and progression of numerous cardiovascular disorders, including coronary heart disease, ischemia-reperfusion injury, cardiomyopathy, arrhythmia, and vascular disease. SP1 emerges as a potential target for the prevention and therapeutic intervention of cardiac ailments. In this review, we delve into the biological functions, pathophysiological mechanisms, and potential clinical implications of SP1 in cardiac pathology to offer valuable insights into the regulatory functions of SP1 in heart diseases and unveil novel avenues for the prevention and treatment of cardiovascular conditions.
摘要：
在哺乳动物中,特异性蛋白1（SP1）是特异性蛋白和Krüppel样因子（Sp/KLF）基因家族中第一个分离出的Cys2-His2锌指转录因子。SP1通过与靶基因启动子区上富含鸟嘌呤-胞嘧啶（GC）的序列结合来调节基因表达，影响各种细胞过程。此外,SP1的活性受到翻译后修饰的显著影响，比如磷酸化，乙酰化,糖基化，和蛋白水解。SP1与细胞凋亡的调节有关，细胞肥大,炎症,氧化应激，脂质代谢，斑块稳定,内皮功能障碍,纤维化，钙化,和其他病理过程。这些过程影响许多心血管疾病的发生和进展，包括冠心病,缺血再灌注损伤,心肌病,心律失常,血管疾病。SP1成为心脏病预防和治疗干预的潜在目标。在这次审查中,我们深入研究生物学功能，病理生理机制，以及SP1在心脏病理学中的潜在临床意义，为SP1在心脏病中的调节功能提供有价值的见解，并揭示预防和治疗心血管疾病的新途径。
