PDF(Pubmed)
Abstract：
Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective selective treatments that could improve the 5-year survival rate. Consequently, the pathophysiological processes within leukemia cells are the focus of critical research. Enzymes such as cystathionine beta-synthase and sulfurtransferases like thiosulfate sulfurtransferase, 3-mercaptopyruvate sulfurtransferase, and cystathionine gamma-lyase play a vital role in cellular sulfur metabolism. These enzymes are essential to maintaining cellular homeostasis, providing robust antioxidant defenses, and supporting cell division. Numerous studies have demonstrated that cancerous processes can alter the expression and activity of these enzymes, uncovering potential vulnerabilities or molecular targets for cancer therapy. Recent laboratory research has indicated that certain leukemia cell lines may exhibit significant changes in the expression patterns of these enzymes. Analysis of the scientific literature and online datasets has confirmed variations in sulfur enzyme function in specific leukemic cell lines compared to normal leukocytes. This comprehensive review collects and analyzes available information on sulfur enzymes in normal and leukemic cell lines, providing valuable insights and identifying new research pathways in this field.
摘要：
白血病是造血系统的癌症，代表着医学科学的重大挑战。白血病细胞的发育涉及细胞机制内的大量干扰，为寻找可以提高5年生存率的有效选择性治疗方法提供了希望。因此,白血病细胞内的病理生理过程是关键研究的焦点。酶，如cystathionalbeta-合酶和硫转移酶，如硫代硫酸盐硫转移酶，3-巯基丙酮酸硫转移酶，和胱硫醚γ-裂解酶在细胞硫代谢中起着至关重要的作用。这些酶对维持细胞稳态至关重要，提供强大的抗氧化防御，支持细胞分裂。许多研究表明，癌变过程可以改变这些酶的表达和活性，发现癌症治疗的潜在漏洞或分子靶标。最近的实验室研究表明，某些白血病细胞系可能在这些酶的表达模式中表现出明显的变化。科学文献和在线数据集的分析证实了与正常白细胞相比，特定白血病细胞系中硫酶功能的变化。这篇全面的综述收集并分析了正常和白血病细胞系中硫酶的可用信息，提供有价值的见解，并确定该领域的新研究途径。
